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Status |
Public on Aug 31, 2017 |
Title |
Characterization of a clival chordoma xenograft model reveals inherent tumor genomic instability |
Organism |
Homo sapiens |
Experiment type |
Genome variation profiling by SNP array
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Summary |
Patient-derived xenografts retain the genotype of the parent tumors more readily than tumor cells maintained in culture. The two reported clival chordoma xenografts are derived from recurrent tumors after radiation. In order to study the genetics of clival chordoma in the absence of prior radiation we sought to establish a patient-derived xenograft at primary resection of a clival chordoma.
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Overall design |
Copy number analysis of primary tumor and 2 PDX passages using Affymetrix SNP6 arrays
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Contributor(s) |
Diaz RJ, Picard D, Remke M, Rutka JT |
Citation missing |
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Submission date |
Aug 31, 2017 |
Last update date |
Jul 25, 2021 |
Contact name |
Marc Remke |
E-mail(s) |
marc.remke@uks.eu
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Organization name |
Universitätsklinikum des Saarlandes
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Department |
Pediatric Translational Oncology Lab
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Street address |
Kirrberger Straße 100, Gebäude 9
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City |
Homburg (Saar) |
State/province |
Saarland |
ZIP/Postal code |
66421 |
Country |
Germany |
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Platforms (1) |
GPL6801 |
[GenomeWideSNP_6] Affymetrix Genome-Wide Human SNP 6.0 Array |
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Samples (3) |
GSM2768928 |
Clivial Chordoma Primary tumour |
GSM2768929 |
Patient Derived Xenograft Serial Passage 0 |
GSM2768930 |
Patient Derived Xenograft Serial Passage 3 |
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Relations |
BioProject |
PRJNA401889 |