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Series GSE102304 Query DataSets for GSE102304
Status Public on Dec 31, 2017
Title Differentially expressed genes related to inflammatory disease on nasal cavity induced by diesel exhaust particles (DEPs)
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Recently air pollution has become serious environmental issues effect. Contaminated air by pollutants, such as emission of diesel fuel, enter the human body through airway tract and can cause inflammatory diseases in respiratory system. The relation between air pollutant and development of respiratory diseases have well-studied, but the processes of disease outbreak were not fully studied yet. We investigated global gene expression induced by diesel exhaust particle (DEP), one of air pollutants in primary human nasal epithelial cell (PHNEC) with the purpose of identifying potential biomarkers. Furthermore, we analyzed signaling pathway among differentially expressed genes (DEGs) for elucidating signaling networks of process developing airway diseases. Consequentially, we suggested several key biomarkers that include not only the expression changes but also the meaning of relation between genes. This findings might be used for early diagnosis and prevention of upper respiratory disease, especially rhinitis.
Overall design Two-dose of DEP treated PHNEC. Biological replicates: 4
Contributor(s) Kim HJ
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Submission date Aug 07, 2017
Last update date Jul 25, 2021
Contact name Hyo-Jeong Kim
Organization name Dongguk University
Street address 32, Dongguk-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do 10326, Republic of Korea
City Goyang
ZIP/Postal code 10326
Country South Korea
Platforms (1)
GPL17077 Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Probe Name version)
Samples (8)
GSM2734286 DEP 50 ug/ml treated PHNEC replicate 1
GSM2734287 DEP 50 ug/ml treated PHNEC replicate 2
GSM2734288 DEP 50 ug/ml treated PHNEC replicate 3
BioProject PRJNA397382

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SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE102304_Processed_data.xlsx 29.5 Mb (ftp)(http) XLSX
GSE102304_RAW.tar 47.1 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table
Processed data are available on Series record

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