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| Status |
Public on Dec 03, 2017 |
| Title |
RNA-seq transcriptonal profiling in mouse hearts under pressure overload |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Heart failure is a leading cause of death in US. Hypertension is one of the most important risk factor of heart failure. In the presence of high blood pressure, the heart manifests hypertrophic growth to ameliorate ventricular wall stress. This once adaptive response may progress into decompensation and heart failure. The precise mechanisms governing this transition remain elusive. Here, we take advantage of mouse surgical model transverce aortic constriction (TAC) to induce pressure overload in rodents. We harvest hearts at different time points post surgery and subject these samples for RNA-Seq analysis with an aim to identify early players in the process and elucidate the molecular mechanisms.
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| |
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| Overall design |
Transcriptional profiling in mouse hearts after pressure overload by RNA-seq analysis.
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| |
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| Contributor(s) |
Wang Y, Zhang Y, Xu J, Wang Z |
| Citation(s) |
28822967 |
| |
| Submission date |
Jul 27, 2017 |
| Last update date |
May 15, 2019 |
| Contact name |
Jian Xu |
| E-mail(s) |
Jian.Xu@stjude.org
|
| Phone |
9015955208
|
| Organization name |
St. Jude Children's Research Hospital
|
| Department |
Pathology
|
| Street address |
262 Danny Thomas Place, MS 345
|
| City |
Memphis |
| State/province |
Tennessee |
| ZIP/Postal code |
38105 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
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| Samples (24)
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| Relations |
| BioProject |
PRJNA396058 |
| SRA |
SRP113727 |
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