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Series GSE101976 Query DataSets for GSE101976
Status Public on Jul 28, 2017
Title Molecular analysis of high-grade serous ovarian carcinoma with and without associated serous tubal intra-epithelial carcinoma [miRNA expression]
Organism Homo sapiens
Experiment type Non-coding RNA profiling by array
Summary Many high-grade serous carcinomas (HGSCs) of the pelvis are thought to originate in the distal portion of the fallopian tube. Serous tubal intraepithelial carcinoma (STIC) lesions are the putative precursor to HGSC and identifiable in ~50% of advanced stage cases. To better understand the molecular etiology of HGSCs, we report a multi-center integrated genomic analysis of advanced stage tumors with and without STIC lesions and normal tissues. The most significant focal DNA SCNAs were shared between cases with and without STIC lesions. RNA sequence and miRNA data did not identify any clear separation between cases with and without STIC lesions. HGSCs had molecular profiles more similar to normal fallopian tube epithelium than ovarian surface epithelium or peritoneum. The data suggest that the molecular features of HGSCs with and without associated STIC lesions are mostly shared, indicating a common biologic origin, likely to be the distal fallopian tube among all cases.
Overall design In this study, 96 previously untreated high-grade serous carcinoma samples were selected to have half with STIC lesions and half without. Molecular assays were performed that included RNAseq, microRNA expression, and copy number variation.
Contributor(s) Levine D, Cope L
Citation(s) 29042553
Submission date Jul 27, 2017
Last update date Jan 24, 2018
Contact name leslie cope
Organization name leslie cope
Street address 550 N. Broadway
City Baltimore
State/province MD
ZIP/Postal code 21209
Country USA
Platforms (1)
GPL17904 nCounter Analysis System, nCounter® Human miRNA Expression Assays
Samples (95)
GSM2719894 HGSC_40187
GSM2719895 HGSC_40190
GSM2719896 HGSC_40193
This SubSeries is part of SuperSeries:
GSE102094 Molecular analysis of high-grade serous ovarian carcinoma with and without associated serous tubal intra-epithelial carcinoma
BioProject PRJNA396052

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE101976_miR.csv.xls.gz 440.4 Kb (ftp)(http) XLS
Processed data included within Sample table
Processed data are available on Series record

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