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Series GSE10088 Query DataSets for GSE10088
Status Public on Feb 11, 2009
Title Time course of MEK inhibition
Organism Homo sapiens
Experiment type Expression profiling by array
Summary This study used microarray expression analysis to identify global changes in transcript alteration in response to MEK inhibition. Genes under ERK control were identified in a representative V600E BRAF cell line as a function of time following exposure to a small molecule inhibitor of MEK.
Keywords: Time course
Overall design SkMel-28 cells growing in culture were treated with the MEK inhibitor PD0325901 for 2, 8, or 24 hours. Changes in RNA compared to reference (time =0) were measured using microarray analysis.
Contributor(s) Pratilas CA, Taylor BS
Citation(s) 19251651
Submission date Jan 07, 2008
Last update date Dec 06, 2018
Contact name Christine Anne Pratilas
Phone 646 888 3121
Organization name Memorial Sloan-Kettering Cancer Center
Department Molecular Pharmacology
Lab Molecular Oncogenesis
Street address 1275 York Avenue
City New York
State/province NY
ZIP/Postal code 10065
Country USA
Platforms (1)
GPL571 [HG-U133A_2] Affymetrix Human Genome U133A 2.0 Array
Samples (4)
GSM254963 SKMEL28-901-timecourse-0HRS
GSM254964 SKMEL28-901-timecourse-2HRS
GSM254965 SKMEL28-901-timecourse-8HRS
This SubSeries is part of SuperSeries:
GSE10086 Expression profiling of V600E BRAF and RTK-activated cells upon MEK inhibition
BioProject PRJNA108973

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE10088_RAW.tar 13.1 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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