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Series GSE10087 Query DataSets for GSE10087
Status Public on Feb 11, 2009
Title Paired MEK inhibited and control
Organism Homo sapiens
Experiment type Expression profiling by array
Summary This study used microarray expression analysis to identify global changes in transcript alteration in response to MEK inhibition. Genes under ERK control were identified in a panel of V600E BRAF and RTK-activated tumor cells and xenografts, using short-term inhibition of ERK activity using the MEK inhibitor PD0325901 (Pfizer).
Keywords: paired treatment and control
Overall design Cell lines growing in culture (n=12) and murine xenografts (n=2) were treated with the MEK inhibitor PD0325901 or vehicle alone as control. Paired analysis of MEK inhibited to control samples was performed for two groups of tumor cells, V600E BRAF and RTK.
Contributor(s) Pratilas CA, Taylor BS
Citation(s) 19251651
Submission date Jan 07, 2008
Last update date Dec 06, 2018
Contact name Christine Anne Pratilas
Phone 646 888 3121
Organization name Memorial Sloan-Kettering Cancer Center
Department Molecular Pharmacology
Lab Molecular Oncogenesis
Street address 1275 York Avenue
City New York
State/province NY
ZIP/Postal code 10065
Country USA
Platforms (1)
GPL571 [HG-U133A_2] Affymetrix Human Genome U133A 2.0 Array
Samples (32)
GSM254931 MDA468-DMSO
GSM254932 MDA468-901
GSM254933 H1650-DMSO
This SubSeries is part of SuperSeries:
GSE10086 Expression profiling of V600E BRAF and RTK-activated cells upon MEK inhibition
BioProject PRJNA108971

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE10087_RAW.tar 107.5 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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