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Series GSE100844 Query DataSets for GSE100844
Status Public on Jul 23, 2018
Title SAMHD1 is recurrently mutated in T-cell prolymphocytic leukemia
Organism Homo sapiens
Experiment type Genome variation profiling by SNP array
SNP genotyping by SNP array
Summary We identified novel recurrent genetic lesions in T-PLL affecting genes involved in JAK/STAT signaling (PTPRC), epigenetic regulation (PRDM2), or DNA damage repair (SAMHD1, PARP10, HERC1, HERC2). Mutations of the tumor suppressor gene SAMHD1 causing amino-acid exchanges or protein truncations as well as copy number variations in SAMHD1 were seen in 20% of cases.
Overall design Copy number variation analysis (Affymetrix SNP 6.0 and CytoHD Arrays) of 14 T-PLL patients.
Contributor(s) Klein-Hitpass L, Johansson P
Citation(s) 29352181
Submission date Jul 05, 2017
Last update date Jul 25, 2021
Contact name Ludger Klein-Hitpass
Phone +49 201 723 85552
Organization name Institut fuer Zellbiologie
Department Universitaetsklinikum
Lab BioChip Lab
Street address Virchowstr. 173
City Essen
ZIP/Postal code D-45122
Country Germany
Platforms (2)
GPL6801 [GenomeWideSNP_6] Affymetrix Genome-Wide Human SNP 6.0 Array
GPL16131 [CytoScanHD_Array] Affymetrix CytoScan HD Array
Samples (14)
GSM2694925 T-PLL_1
GSM2694926 T-PLL_8
GSM2694927 T-PLL_2
BioProject PRJNA393223

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE100844_RAW.tar 868.6 Mb (http)(custom) TAR (of CEL, CHP, CYCHP)
Processed data included within Sample table
Processed data provided as supplementary file

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