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Series GSE100338 Query DataSets for GSE100338
Status Public on Jun 22, 2017
Title Expression profiling of lncRNAs, miRNAs and mRNAs and their differential expression in leiomyoma using next generation RNA sequencing
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Non-coding RNA profiling by high throughput sequencing
Summary Total RNA was isolated from leiomyoma and paired myometrium (N=8) and samples from three pairs were subjected to RNA sequencing. After analysis, 5941 lncRNAs (2813 up- and 3128 down-regulated at ≥1.5 fold), 148 miRNAs (56 up- and 96 down-regulated at ≥1.5 fold) and 3855 mRNAs (2030 up- and 1855 down-regulated at ≥1.5 fold) were differentially expressed in leiomyomas. Using QRT-PCR we further confirmed the expression of HULC, lnc-MEG3, LINC00890, TSIX, LINC00473, lnc-KLF9-1 and lnc-POTEM-3 (lncRNA-ATB) in leiomyoma and matched myometrium (N=8). Our results presented here provide a comprehensive expression profile of lncRNAs in leiomyomas with concurrent integrated expression of miRNAs and mRNAs in leiomyomas.
Overall design Identify the expression profile of lncRNAs with concurrent assessment of miRNAs and mRNAs profiles in leiomyomas and paired myometrium using next generation RNA sequencing
Contributor(s) Chuang T, Khorram O
Citation(s) 28587571
Submission date Jun 21, 2017
Last update date May 15, 2019
Contact name Tsai-Der Chuang
Phone 310-222-1897
Organization name LA Biomed at UCLA medical center
Department OB-GYN
Lab Omid Khorram
Street address 1124 WEST CARSON STREET
City Torrance
State/province California
ZIP/Postal code 90502
Country USA
Platforms (1)
GPL21290 Illumina HiSeq 3000 (Homo sapiens)
Samples (6)
GSM2678105 189M
GSM2678106 189L
GSM2678107 190M
BioProject PRJNA391373
SRA SRP110081

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE100338_CAP_miRSeq_count_miRNA_.txt.gz 14.9 Kb (ftp)(http) TXT
GSE100338_TMM_normalized_reads_count_per_million_lncRNA_.txt.gz 778.2 Kb (ftp)(http) TXT
GSE100338_TMM_normalized_reads_count_per_million_mRNA_.txt.gz 951.7 Kb (ftp)(http) TXT
GSE100338_TMM_normalized_reads_count_per_million_miRNA_.txt.gz 33.0 Kb (ftp)(http) TXT
GSE100338_X183_FC1.5_pVal0.05_15_genes.txt.gz 1.1 Kb (ftp)(http) TXT
GSE100338_X183_FC1.5_pVal0.05_520_genes.txt.gz 27.5 Kb (ftp)(http) TXT
GSE100338_X183_FC1.5_pVal0.05_913_genes.txt.gz 66.6 Kb (ftp)(http) TXT
GSE100338_X189_FC1.5_pVal0.05_1128_genes.txt.gz 82.0 Kb (ftp)(http) TXT
GSE100338_X189_FC1.5_pVal0.05_42_genes.txt.gz 2.8 Kb (ftp)(http) TXT
GSE100338_X189_FC1.5_pVal0.05_792_genes.txt.gz 38.5 Kb (ftp)(http) TXT
GSE100338_X190_FC1.5_pVal0.05_12_genes.txt.gz 950 b (ftp)(http) TXT
GSE100338_X190_FC1.5_pVal0.05_414_genes.txt.gz 19.3 Kb (ftp)(http) TXT
GSE100338_X190_FC1.5_pVal0.05_470_genes.txt.gz 34.8 Kb (ftp)(http) TXT
GSE100338_rsem_count_lncRNA_.txt.gz 541.2 Kb (ftp)(http) TXT
GSE100338_rsem_count_mRNA_.txt.gz 361.7 Kb (ftp)(http) TXT
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Processed data are available on Series record

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