DUX/DUX4 activation is coupled to p53 signaling in embryos, 2C-like cells, and FSHD patient cells

Hyperglycaemia induces trained immunity in macrophages and their precursors and promotes atherosclerosis

Chromatin architecture of B cell development during the humoral immune response

Disruption of higher order nuclear condensates by a dominant negative FOXN1 mutation causes immunodeficiency

Epigenetic basis of oncogenic-Kras mediated epithelial-cellular proliferation and plasticity

Tumor-induced double positive T cells display distinct lineage commitment mechanisms and functions

Pancreas agenesis mutations disrupt a lead enhancer controlling a developmental enhancer cluster

KLF5 governs sphingolipid metabolism and barrier function of the skin

ZNF384 fusion oncoproteins drive lineage aberrancy in acute leukemia

A non-coding single nucleotide polymorphism at 8q24 drives IDH1-mutant glioma formation

Balanced SET levels favor the correct enhancer repertoire during cell fate acquisition

Elevated expression of histone deacetylase HDAC8 suppresses arginine-proline metabolism in necrotizing enterocolitis [PCI34051 study]

Unique Transcriptional Profiles Underlie Osteosarcomagenesis Driven by Different p53 Mutants

DNA-guided transcription factor cooperativity shapes face and limb mesenchyme

Pbrm1 regulates interferon signaling in mouse AML

Single-nucleus multiomic mapping of m6A methylome and transcriptome in native populations of cells with sn-m6A-CT

Identifying gene combinations for targeting innate immune cells to enhance T cells activation

Multiomic Single Cell Evaluation Reveals Inflammatory Cytokines Affect Innate Lymphoid Cell Fate After Allogeneic Stem Cell Transplantation

ARID1A Orchestrates SWI/SNF-mediated Sequential Binding of Transcription Factors with ARID1A Loss Driving Pre-memory B Cell Fate and Lymphomagenesis

Cooperative super-enhancer inactivation caused by heterozygous loss of CREBBP and KMT2D skews B-cell fate decisions and accelerates development of T-cell depleted lymphomas.