Topoisomerase 1 Nicking-dependent HP1gamma Engagement Mediates Acute Activation of Phase-separated Enhancers

TAD Evolutionary and functional characterization reveals diversity in mammalian TAD boundary properties and function

MAFG-driven astrocytes promote CNS inflammation

Nutrient regulation of the islet epigenome controls adaptive insulin secretion

Fat1 deletion promotes hybrid EMT state with enhanced tumor progression, stemness, and metastasis

Tcf1 is essential for initiation of oncogenic Notch1-driven chromatin topology.

Combinatorial effects on gene expression at the Lbx1/Fgf8 locus resolve Split-Hand/Foot Malformation type 3

Short C-terminal Musashi-1 proteins regulate pluripotency states in embryonic stem cells

LIS1 RNA-binding orchestrates the mechanosensitive properties of embryonic stem cells in AGO2-dependent and independent ways

BORIS/CTCFL epigenetically reprograms clustered CTCF binding sites into alternative transcriptional start sites.

Outward-oriented sites within clustered CTCF boundaries are key for intraTAD chromatin interactions and gene regulation

U1 snRNP increases RNA Pol II elongation rate to enable synthesis of long genes [RNA-Seq]

A multiscale 3D chromatin architecture that controls development of the humoral immune system is assembled by IKAROS

SMYD5 is a regulator of the mild hypothermia response

Synthetic essentiality of thymine DNA glycosylase in p53-deficient cancer

Genome-wide interference of chromatin architecture and Mediator in transcriptional bursting and gene network regulation

XIST directly regulates X-linked and autosomal genes in naïve human pluripotent cells

Opposing tumor cell-intrinsic and -extrinsic roles of the IRF1 transcription factor in anti-tumor immunity

Engineered extrachromosomal oncogene amplifications promote tumorigenesis