A multiscale 3D chromatin architecture that controls development of the humoral immune system is assembled by IKAROS

BORIS/CTCFL epigenetically reprograms clustered CTCF binding sites into alternative transcriptional start sites.

Combinatorial effects on gene expression at the Lbx1/Fgf8 locus resolve Split-Hand/Foot Malformation type 3

Engineered extrachromosomal oncogene amplifications promote tumorigenesis

Fat1 deletion promotes hybrid EMT state with enhanced tumor progression, stemness, and metastasis

Genome-wide interference of chromatin architecture and Mediator in transcriptional bursting and gene network regulation

LIS1 RNA-binding orchestrates the mechanosensitive properties of embryonic stem cells in AGO2-dependent and independent ways

MAFG-driven astrocytes promote CNS inflammation

Nutrient regulation of the islet epigenome controls adaptive insulin secretion

Opposing tumor cell-intrinsic and -extrinsic roles of the IRF1 transcription factor in anti-tumor immunity

Outward-oriented sites within clustered CTCF boundaries are key for intraTAD chromatin interactions and gene regulation

SMYD5 is a regulator of the mild hypothermia response

Short C-terminal Musashi-1 proteins regulate pluripotency states in embryonic stem cells

Synthetic essentiality of thymine DNA glycosylase in p53-deficient cancer

TAD Evolutionary and functional characterization reveals diversity in mammalian TAD boundary properties and function

Tcf1 is essential for initiation of oncogenic Notch1-driven chromatin topology.

Topoisomerase 1 Nicking-dependent HP1gamma Engagement Mediates Acute Activation of Phase-separated Enhancers

U1 snRNP increases RNA Pol II elongation rate to enable synthesis of long genes [RNA-Seq]

XIST directly regulates X-linked and autosomal genes in naïve human pluripotent cells