Polycomb Mediated Chromatin Organization Reveals Transcriptional Silencers Required for Embryonic Development

EOMES-dependent epigenetic reprogramming during CD8 T cell development leads to acquisition of memory traits

Defining the relative and combined contribution of CTCF and CTCFL to genomic regulation

H3K27me3 maintains the transcription program during epigenetic reprogramming in the mouse germ line

BACH1 Recruits NANOG and Histone H3 Lysine 4 Methyltransferase MLL/SET1 Complexes to Regulate Enhancer-promoter Activity and Maintains Pluripotency

Non-Canonical Targets of HIF1a Impair Oligodendrocyte Progenitor Cell Function

Epigenetic control of cellular cross-talk defines organ fate and function

SWI/SNF inactivation in the endometrial epithelium leads to loss of epithelial integrity

Differential chromatin binding of the lung lineage transcription factor NKX2-1 resolves opposing murine alveolar cell fates in vivo

H3K27me3 shapes DNA methylome by inhibiting UHRF1-mediated H3 ubiquitination

SETDB1/NSD dependent H3K9me3/H3K36me3 dual heterochromatin maintains gene expression profiles by bookmarking poised enhancers

ZFP462 safeguards neural lineage specification by targeting G9A/GLP mediated heterochromatin to silence enhancers

Inheritance of Repressed Chromatin Domains during S-phase Requires the Histone Chaperone NPM1

Pancreas agenesis mutations disrupt a lead enhancer controlling a developmental enhancer cluster

Co-existing TP53 and ARID1A mutations promote aggressive endometrial tumorigenesis

A phenotypic screening platform for identifying chemical modulators of astrocyte reactivity

Obox4 secures zygotic genome activation upon loss of Dux

Macrophage

Cooperative ETS Transcription Factors Enforce Adult Endothelial Cell Fate and Cardiovascular Homeostasis

Single genomic enhancers drive experience-dependent GABAergic plasticity to maintain sensory processing in the adult cortex