Probing cell identity hierarchies by fate titration and collision during direct reprogramming [scRNA-seq & scATAC-seq]

Tabula Muris

Tabula Muris Senis

Activity-dependent modulation of synapse-regulating genes in astrocytes

Arthritogenic SKG T cells have a transcriptional program of activation and a repertoire pruned by superantigen

Reversal of lineage plasticity in RB1/TP53-deleted prostate cancer through FGFR and Janus kinase inhibition

Conserved transcriptional connectivity of regulatory T cells in the tumor microenvironment informs novel combination cancer therapy strategies [mouse]

Epigenetic plasticity cooperates with emergent cell-cell interactions to drive neoplastic tissue remodeling in the pancreas [scRNA-seq]

Terminal differentiation and persistence of effector regulatory T cells essential for the prevention of intestinal inflammation

Time series single-cell RNA sequencing of murine hematopoetic stem and progenitors (HSPCs) following in vivo IFNα treatment

Deep dynamical modelling of developmental trajectories with temporal transcriptomics

Control of nutrient uptake by IRF4 orchestrates innate immune memory - scRNA-seq

Control of nutrient uptake by IRF4 orchestrates innate immune memory

Red blood cells-heme-exposure and tumor-associated macrophage identity

Hemorrhage-induced NRF2 signaling in tumor-associated macrophages drives cancer growth, invasion, and immunotherapy resistance

Unleashing natural IL-18 activity using an anti-IL-18BP blocker antibody induces potent immune stimulation and anti-tumor effects

Age-related epithelial defects limit thymic function and regeneration [single cell]

Alveolar differentiation drives resistance to KRAS inhibition in lung adenocarcinoma [scRNA-seq]

Alveolar differentiation drives resistance to KRAS inhibition in lung adenocarcinoma

Single-cell and spatial profiling identify three response trajectories to pembrolizumab and radiation therapy in triple negative breast cancer