Inhibition of SWI/SNF broadly disrupts enhancers and reveals remodeler redundancy at promoters

Rational design of a SOCS1-edited tumor infiltrating lymphocyte therapy for solid tumors using CRISPR/Cas9 screens

Joint epigenome profiling reveals cell-type-specific gene regulatory programs in human cortical organoids

Enhancer grammar of liver cell types and hepatocyte zonation states

Genome editing by dual nucleases records deep lineage hierarchy with high fidelity.

Transcriptomics of skin reveal potential molecular mechanisms of psoriasis

A single cell atlas of human glioma under therapy

Decoding the immune checkpoint signatures in human atherosclerosis: implications of type 2 diabetes and lipid-lowering intervention

Single-nucleus multiomic mapping of m6A methylome and transcriptome in native populations of cells with sn-m6A-CT [scRNA-seq, scCUT&Tag]

Single-nucleus multiomic mapping of m6A methylome and transcriptome in native populations of cells with sn-m6A-CT

A Lactate-induced SREBF2-dependent genetic program drives an immunotolerant dendritic cell population during cancer progression

Impaired proteolysis of non-canonical RAS proteins drives clonal hematopoietic transformation

Dissecting developmental disorders caused by CTCF mutation at R567

HOTTIP reinforces CTCF-defined TAD boundaries by forming R-loops to drive Wnt/b-catenin target gene expression in AML leukemogenesis

Genome-wide interference of chromatin architecture and Mediator in transcriptional bursting and gene network regulation

Identification of rejection-associated indirect CD4 T cell epitopes provides a target for donor-specific transplant tolerance

ChromaFold predicts the 3D contact map from single-cell chromatin accessibility

Tau aggregates are RNA-protein assemblies that mis-localize multiple nuclear speckle components

Genome-Wide CRISPR Screen Identifies Multiple Synthetic Lethal Targets That Enhance KRAS (G12C) Inhibitor Efficacy

Targeting Immune-Fibroblast Crosstalk in Myocardial Infarction and Cardiac Fibrosis