Rational design of a SOCS1-edited tumor infiltrating lymphocyte therapy for solid tumors using CRISPR/Cas9 screens

Genome editing by dual nucleases records deep lineage hierarchy with high fidelity.

Dual nuclease single-cell lineage tracing by Cas9 and Cas12a

Transcriptomics of skin reveal potential molecular mechanisms of psoriasis

A single cell atlas of human glioma under therapy

Decoding the immune checkpoint signatures in human atherosclerosis: implications of type 2 diabetes and lipid-lowering intervention

Single-nucleus multiomic mapping of m6A methylome and transcriptome in native populations of cells with sn-m6A-CT [scRNA-seq, scCUT&Tag]

Single-nucleus multiomic mapping of m6A methylome and transcriptome in native populations of cells with sn-m6A-CT

A Lactate-induced SREBF2-dependent genetic program drives an immunotolerant dendritic cell population during cancer progression

Impaired proteolysis of non-canonical RAS proteins drives clonal hematopoietic transformation

Dissecting developmental disorders caused by CTCF mutation at R567

HOTTIP reinforces CTCF-defined TAD boundaries by forming R-loops to drive Wnt/b-catenin target gene expression in AML leukemogenesis

Genome-wide interference of chromatin architecture and Mediator in transcriptional bursting and gene network regulation

Genome-Wide CRISPR Screen Identifies Multiple Synthetic Lethal Targets That Enhance KRAS (G12C) Inhibitor Efficacy

Targeting Immune-Fibroblast Crosstalk in Myocardial Infarction and Cardiac Fibrosis

An activity-specificity trade-off encoded in human transcription factors

Molecular reframing of fibroblasts during resolution of arthritis

Epithelial-Immune Metabolic Codependency Fuels Inflammatory Disease

ETV6 Represses Inflammatory Response Genes and Regulates HSPC Function During Stress Hematopoiesis in Mice

MYC drives temporal evolution of small cell lung cancer subtypes by reprogramming neuroendocrine fate [SuperSeries]