The Dynamic Epigenetic Landscape of the Retina During Development, Reprogramming, and Tumorigenesis

MYC drives temporal evolution of small cell lung cancer subtypes by reprogramming neuroendocrine fate [SuperSeries]

Transcriptomics of skin reveal potential molecular mechanisms of psoriasis

HOTTIP reinforces CTCF-defined TAD boundaries by forming R-loops to drive Wnt/b-catenin target gene expression in AML leukemogenesis

A single cell atlas of human glioma under therapy

Impaired proteolysis of non-canonical RAS proteins drives clonal hematopoietic transformation

RNA helicase DHX15 exemplifies a unique dependency in acute leukemia

Netrin-1 blockade induces tumor growth inhibition and EMT reversion in endometrial cancer.

heart healthy and heart diseased SCGs

Rational design of a SOCS1-edited tumor infiltrating lymphocyte therapy for solid tumors using CRISPR/Cas9 screens

ETV6 Represses Inflammatory Response Genes and Regulates HSPC Function During Stress Hematopoiesis in Mice

A genetic-metabolic axis for metastatic liver organotropism

Single-nucleus multiomic mapping of m6A methylome and transcriptome in native populations of cells with sn-m6A-CT [scRNA-seq, scCUT&Tag]

Single-nucleus multiomic mapping of m6A methylome and transcriptome in native populations of cells with sn-m6A-CT

IL-1b+ tumor-associated macrophages fuel pathogenic inflammation in pancreatic cancer

Genome-Wide CRISPR Screen Identifies Multiple Synthetic Lethal Targets That Enhance KRAS (G12C) Inhibitor Efficacy

Molecular reframing of fibroblasts during resolution of arthritis

An activity-specificity trade-off encoded in human transcription factors

Epithelial-Immune Metabolic Codependency Fuels Inflammatory Disease

Histone lactylation antagonizes senescence and skeletal muscle aging via facilitating gene expression reprogramming