Genome editing by dual nucleases records deep lineage hierarchy with high fidelity.

Genome-wide interference of chromatin architecture and Mediator in transcriptional bursting and gene network regulation

Open-ST: High-resolution spatial transcriptomics in 3D

Dissecting developmental disorders caused by CTCF mutation at R567

Epithelial-Immune Metabolic Codependency Fuels Inflammatory Disease

Programmable transcript-specific enrichment for single-cell sequencing enables profiling of rare cell states

An activity-specificity trade-off encoded in human transcription factors

Molecular reframing of fibroblasts during resolution of arthritis

Mitochondrial RNA-seq and total RNA-seq of 293T, HeLa, and N2a cells; RIP-seq of SUPV3L1, ceSUPV3L1, ATP5B, and TRAP1; Small RNA-seq of 293T mitochondrial fractions

A Massively Parallel Screen of 5′UTR Mutations Identifies Variants Impacting Translation and Protein Production in Neurodevelopmental Disorder Genes

Single-cell 3D Genome and Multiome of the Human and Mouse Cerebellum

IL-1b+ tumor-associated macrophages fuel pathogenic inflammation in pancreatic cancer

Single-nucleus multiomic mapping of m6A methylome and transcriptome in native populations of cells with sn-m6A-CT [Bulk CUT&Tag]

Single-nucleus multiomic mapping of m6A methylome and transcriptome in native populations of cells with sn-m6A-CT [scRNA-seq, scCUT&Tag]

Single-nucleus multiomic mapping of m6A methylome and transcriptome in native populations of cells with sn-m6A-CT

A genetic-metabolic axis for metastatic liver organotropism

Development of nanoRibo-seq enables study of regulated translation by cortical neuron subtypes, showing uORF translation in synaptic-axonal genes

Rational design of a SOCS1-edited tumor infiltrating lymphocyte therapy for solid tumors using CRISPR/Cas9 screens

Decoder-seq enhances mRNA capture efficiency in spatial RNA sequencing

Single-cell TCR-sequencing of T cells in crescentic glomerulonephritis