Multiplexed inhibition of immunosuppressive genes with Cas13d for on-demand combinatorial cancer immunotherapy

USP5 stabilizes YTHDF1 to control cancer immune surveillance through mTORC1-mediated phosphorylation

CRIPTO’s multifaceted role in driving aggressive prostate cancer unveiled by in vivo, organoid, and patient data

A lineage-specific nascent RNA assay unveils principles of gene regulation in tissue biology.

Dysregulated regulatory T cell responses expand fibroblasts and lead to chronic rejection after heart transplantation

Rac1 impairs retinal axon degeneration via Kif2a in a mouse model of chronic ocular hypertension

Improved split prime editors enable efficient in vivo genome editing [Amplicon_Seq_in_vitro]

Intestinal Akkermansia muciniphila complements the therapeutic efficacy of PD1 therapy by reshaping the immunosuppressive microenvironment in nonalcoholic fatty liver disease (NAFLD)-induced hepatocellular carcinoma

Proline exacerbates hepatic gluconeogenesis via paraspeckle-dependent mRNA retention [RIP-Seq]

Proline exacerbates hepatic gluconeogenesis via paraspeckle-dependent mRNA retention

Aberrant homeodomain-DNA cooperative dimerization underlies distinct developmental defects in two dominant CRX retinopathy models

Dcp1a, a novel Mek substrate, regulates the self-renewal and differentiation of mouse embryonic stem cells [Ribo-seq]

Spatiotemporal transcriptomic map of glial cell response in a mouse model of acute brain ischemia

Inducible deletion of Ezh2 in CD4+ T cells inhibits kidney T cell infiltration and prevents interstitial nephritis in MRL/lpr lupus-prone mice

Lipid-orchestrated paracrine circuit coordinates mast cell maturation and anaphylaxis through functional interaction with fibroblasts [skin scRNA-seq]

NOTCH1 orchestrates a multifaceted malignant and immune evasion program in hepatocellular carcinoma

RNA helicase D1PAS1 resolves R-loops and forms a complex for mouse pachytene piRNA biogenesis required for male fertility

An Intrinsic Disorder Region Controlling Condensation of a Circadian Clock Component and Rhythmic Transcription in the Liver [ChIA-PET]

An Intrinsically Disordered Region Controlling Condensation of a Circadian Clock Component and Rhythmic Transcription in the Liver

SNORD113-114 cluster regulates self-renewal of hematopoietic stem cells via orchestrating the translation machinery