3D structures of individual mammalian genomes reveal principles of nuclear organization

mRNA destabilization by BTG1 and BTG2 maintains T cell quiescence

Gene regulation by gonadal hormone receptors defines brain sex differences

IL-23 promotes a coordinated B-cell germinal center program for class-switch recombination to IgG2b in BXD2 mice

Role of the metabolic sensor AMP-activated protein kinase in T cell function in vivo

Coupled analysis of transcriptional states and somatic hypermutation in germinal center B cells reveals role for oxidative phosphorylation in positive selection

T cell receptor is required for differentiation but not maintenance of intestinal CD4+ intraepithelial lymphocytes

In vivo adenine base editing of PCSK9 in mice and macaques reduces LDL-cholesterol levels

Single-cell atlas reveals meningeal leukocyte heterogeneity in the developing mouse brain

Neurons burdened by DNA double strand breaks incite microglia activation through antiviral-like signaling in neurodegeneration.

Single-cell gene expression of virus-specific CD4 T cells in response to acute and chronic infection

Clonal lineage tracing reveals shared origin of conventional and plasmacytoid dendritic cells

Newly recruited intraepithelial Ly6A+CCR9+CD4+ T cells protect against enteric viral infection

Variant-specific vaccination induces systems immune responses and potent in vivo protection against SARS-CoV-2

A ketogenic diet can revert acquired resistance to immunotherapy in prostate cancer through β-hydroxybutyrate-mediated inhibition of histone deacetylases

Probing cell identity hierarchies by fate titration and collision during direct reprogramming

A mouse model with high clonal barcode diversity for joint lineage, transcriptomic, and epigenomic profiling in single cells

A monoclonal Trd chain supports the development of the complete set of functional γδ T cell lineages

Molecular characterization stratifies VQ myeloma cells into two clusters with distinct risk signatures and drug responses

ZNF143 is a transcriptional regulator of nuclear-encoded mitochondrial genes that acts independently of looping and CTCF