A mouse model with high clonal barcode diversity for joint lineage, transcriptomic, and epigenomic profiling in single cells

In vivo adenine base editing of PCSK9 in mice and macaques reduces LDL-cholesterol levels

Responders to immune checkpoint therapy display early clonal expansion of tumour-infiltrating lymphocytes

Variant-specific vaccination induces systems immune responses and potent in vivo protection against SARS-CoV-2

Clonal lineage tracing reveals shared origin of conventional and plasmacytoid dendritic cells

Gene regulation by gonadal hormone receptors defines brain sex differences

ZNF143 is a transcriptional regulator of nuclear-encoded mitochondrial genes that acts independently of looping and CTCF

Large-scale analysis of the integration of enhancer-enhancer signals by promoters

Composition of colonic microbes in mice deficient in intestinal Treg subsets

Neurons burdened by DNA double strand breaks incite microglia activation through antiviral-like signaling in neurodegeneration.

Systematic analysis of intrinsic enhancer-promoter compatibility in the mouse genome.

DSS-colitis induced in young age accelerates the onset of cognitive defects in Tg2576 mice, a model of Alzheimer disease

3D structures of individual mammalian genomes reveal principles of nuclear organization

Identification of rejection-associated indirect CD4 T cell epitopes provides a target for donor-specific transplant tolerance

Molecular characterization stratifies VQ myeloma cells into two clusters with distinct risk signatures and drug responses

TCR sequencing data from responders and progressors to cyclophosphamide chemotherapy

T cell receptor is required for differentiation but not maintenance of intestinal CD4+ intraepithelial lymphocytes

Role of the metabolic sensor AMP-activated protein kinase in T cell function in vivo

T cell AHR activity tunes the Gut Microenvironment to Sustain Autoimmunity [sephouse_cecum]

Coupled analysis of transcriptional states and somatic hypermutation in germinal center B cells reveals role for oxidative phosphorylation in positive selection