Antigen cross-presentation in young tumor-bearing hosts promotes CD8 T cell terminal differentiation

Induction of mouse totipotent stem cells by a defined chemical cocktail

Single-cell multi-omics in human clonal hematopoiesis reveals that DNMT3A R882 mutations perturb early progenitor states through selective hypomethylation.

Hypoxia induces an early primitive streak signature, enhancing spontaneous elongation and lineage representation in gastruloids

Inhibition of mutant IDH1 promotes cycling of acute myeloid leukemia stem cells

Multimodal profiling of the transcriptional regulatory landscape of the developing mouse cortex identifies Neurog2 as a key epigenome remodeler

CDCA7-associated global aberrant DNA hypomethylation translates to localized, tissue-specific transcriptional responses

Inducible disruption of Tet genes results in myeloid malignancy, readthrough transcription, and a heterochromatin-to-euchromatin switch

Beta cell-specific CD8+ T cells maintain stem-cell memory-associated epigenetic programs during type 1 diabetes

STAT3 inhibition permits epigenetic reprogramming and TLR9/IRF8-driven differentiation of inv(16) acute myeloid leukemia.

YTHDF2 inhibition potentiates radiotherapy by reprogramming suppressive myeloid cells

Antitumor progenitor exhausted CD8 T cells are sustained with TCR engagement

germ cells

Epigenetic regulator function through mouse gastrulation

Dnmt3a-Mutant Hematopoietic Stem cells are resistant to inflammatory stress

Single substitution in H3.3G34 alters DNMT3A recruitment to cause progressive neurodegeneration

Direct neuronal reprogramming of mouse astrocytes is associated with multiscale epigenome remodeling and requires Yy1

LN-stem, tumor stem, tumor terminally differentiated CD8 T cells from human kidney cancer

Synthetic essentiality of thymine DNA glycosylase in p53-deficient cancer

Dual gene activating and repressive functions of TET1 in germ layer lineage bifurcation distinguished by genomic context and dependence on 5-methylcytosine oxidation