A multiscale 3D chromatin architecture that controls development of the humoral immune system is assembled by IKAROS

BORIS/CTCFL epigenetically reprograms clustered CTCF binding sites into alternative transcriptional start sites.

Engineered extrachromosomal oncogene amplifications promote tumorigenesis

Fat1 deletion promotes hybrid EMT state with enhanced tumor progression, stemness, and metastasis

Genome-wide interference of chromatin architecture and Mediator in transcriptional bursting and gene network regulation

High-resolution transcriptional analysis of immunoglobulin variable regions reveals the absence of direct relationships between somatic hypermutation, nascent transcription and epigenetic marks

LIS1 RNA-binding orchestrates the mechanosensitive properties of embryonic stem cells in AGO2-dependent and independent ways

MAFG-driven astrocytes promote CNS inflammation

Nutrient regulation of the islet epigenome controls adaptive insulin secretion

Opposing tumor cell-intrinsic and -extrinsic roles of the IRF1 transcription factor in anti-tumor immunity

Outward-oriented sites within clustered CTCF boundaries are key for intraTAD chromatin interactions and gene regulation

Outward-oriented sites within clustered CTCF boundaries are key for intraTAD chromatin interactions and gene regulation [ChIP-seq]

Putative looping factor ZNF143/ZFP143 is an essential transcriptional regulator with no looping function.

SMYD5 is a regulator of the mild hypothermia response

Synthetic essentiality of thymine DNA glycosylase in p53-deficient cancer

TAD Evolutionary and functional characterization reveals diversity in mammalian TAD boundary properties and function

Tcf1 is essential for initiation of oncogenic Notch1-driven chromatin topology.

Topoisomerase 1 Nicking-dependent HP1gamma Engagement Mediates Acute Activation of Phase-separated Enhancers

XIST directly regulates X-linked and autosomal genes in naïve human pluripotent cells