Argonautes promote male fertility and provide a paternal memory of germline gene expression in C. elegans

High throughput sequencing of mutants in the WAGO pathway

Sequential rounds of RNA-dependent RNA transcription drive endogenous small-RNA biogenesis in ERGO-1/Argonaute pathway

High throughput sequencing of endogenous small RNAs from AGO pathway mutants

C. elegans piRNAs mediate the genome-wide surveillance of germline transcripts

piRNAs initiate an epigenetic memory of non-self RNA in the C. elegans germline.

C. elegans piRNAs are processed from capped-small RNAs transcribed at promoters throughout the genome

The C. elegans CSR-1 argonaute pathway counteracts epigenetic silencing to promote germline gene expression

The Vasa homolog RDE-12 engages target mRNA and a secondary-Argonaute WAGO-1 to promote RNAi in C. elegans