In vivo single-cell CRISPR uncovers distinct TNF-α programs in tumor evolution

NFI transcription factors regulate zonal olfactory receptor expression

Spatiotemporal hepatocyte heterogeneity impacts in vivo gene engineering [Visium Spatial Transcriptomics]

Spatiotemporal hepatocyte heterogeneity impacts in vivo gene engineering

Zfp281 and Zfp148 control CD4+ T cell thymic development and Th2 functions

The transcription factor Zfp281 serves redundantly with Zfp148 to support CD4+ T cell development and functions [Thymus Visium]

Spatial transcriptome analysis defines heme as a hemopexin-targetable inflammatoxin in the brain

Aging- and Alcohol-Associated Spatial Transcriptomic Signature in Mouse Acute Pancreatitis

Resident Macrophage Subpopulations Occupy Distinct Microenvironments in the Kidney

Helicase-like transcription factor (Hltf)-deletion activates Hmgb1-Rage axis and granzyme A-mediated killing of pancreatic β cells resulting in neonatal lethality

Helicase-like transcription factor (HLTF)-deleted CDX/TME model of colorectal cancer increased transcription of oxidative phosphorylation genes and diverted glycolysis to boost S-glutathionylation in intravascular metastatic niches [Spatial]

Helicase-like transcription factor (HLTF)-deleted CDX/TME model of colorectal cancer increased transcription of oxidative phosphorylation genes and diverted glycolysis to boost S-glutathionylation in intravascular metastatic niches

Spatial transcriptomics reveals distinct tumor microenvironment of murine breast cancer model undergoing treatment with a humanized monoclonal antibody targeting FABP4

Nextflow Pipeline for Visium and H&E Data from Patient-Derived Xenograft Samples

Multimodal spatiotemporal transcriptomic resolution of embryonic palate osteogenesis

Multimodal spatiotemporal transcriptomic resolution of embryonic palate osteogenesis [Spatial Transcriptomics]

MacroH2A restricts melanoma progression via inhibition of chemokine expression in cancer-associated fibroblasts.

MacroH2A restricts melanoma progression via inhibition of chemokine expression in cancer-associated fibroblasts [spatial transcriptomics]

Aristolochic Acid Nephropathy 2 week time point of CD45+ cells

Fragment-sequencing unveils local tissue microenvironments at single cell resolution