FoxP3 associates with enhancer-promoter loops to regulate Treg-specific gene expression [ATAC-seq]

FoxP3 associates with enhancer-promoter loops to regulate Treg-specific gene expression

Single-cell epigenomics and high-density genetic variation resolve the architecture of the Treg regulatory network [scATAC-seq]

Thymic epithelial cells co-opt lineage-defining transcription factors to eliminate autoreactive T cells

Single-cell RNAseq (10x Genomics) analysis of mouse splenic CD4+ T cells in WT and ∆Foxp3 mice and in WT/∆Foxp3 bone marrow chimeras

Single-cell RNAseq (10x Genomics) analysis of human CD4+ T cells in IPEX patients, healthy donors and heterozygous mothers (blood).

PPARg marks splenic precursors of multiple nonlymphoid-tissue Treg compartments [scRNA-seq multiple tissues]

PPARg marks splenic precursors of multiple nonlymphoid-tissue Treg compartments

Impact of bacterial mono-colonization on intestinal and splenic CD4 T cells responses

Adipose-tissue regulatory T cells are a consortium of subtypes that evolves with age and diet

PPARg marks splenic precursors of multiple nonlymphoid-tissue Treg compartments [scRNA-seq spleen]

Thymic epithelial cells co-opt lineage-defining transcription factors to eliminate autoreactive T cells [scRNA-seq]

Single-cell expression profiling of visceral adipose tissue and splenic CD4+ T cells from Treg-bmal1WT and Treg-bmal1KO mice at ZT0 and ZT12.

Investigation of Thymic TCRd+ cells

Hnf4 controls gut and liver gene programs in the thymus [scRNAseq]

Mutations from IPEX patients elicit a range of phenotypes in mice [scATAC-Seq]

Mutations from IPEX patients elicit a range of phenotypes in mice

Homeostatic, repertoire and transcriptional relationships between colon T regulatory cell subsets

A chemogenetic screen for neuro-immune interactions in the gut: Trpv1+ nociceptor neurons control T regulatory cells

Single cell RNA sequencing immune cells (macrophages, CD4 T and B cells) from male and female mice, at 0,1,2,3 hours after IFNa injection.