EGR2 is upregulated in monocyte-derived macrophages in MASH liver

EGR2 is required for the acquisition of hLAM phenotype by monocyte-derived macrophages in MASH.

RNA-seq analysis of naïve and MASH liver tissue.

EGR2 biases the differentiation of liver infiltrating monocytes into hLAMs.

CD11c and Mincle discriminates hLAMs from moKCs in MASH liver

The chromatin structures of GMP-MoPs are shifted toward ones that favors an aberrant differentiation pathway generating GMP-MoPs from proNeu1 [ATAC-seq]

Human CXCR1+CD14+ monocytes are characterized by neutrophil-associated gene expression [RNA-seq human]

GMP-MoPs display mixed gene expression profiles of both neutrophil and monocyte progenitors [RNAseq mouse]

GMP-MoPs can be classified as an independent cell type that differentiate from GMPs through proNeu1 without going through the MDP-cMoP pathway [scRNA-seq]

mouse RNA-seq, human RNA-seq, ATAC-seq, and scRNA-seq analyses data