Tabula Muris

Tabula Muris Senis

Rescuing voluntary motor behavior in a Parkinson´s disease model by aCRISPR mediated reprogramming of striatal astrocytes into induced GABAergic neurons

Single cell RNA seq of hepatic and renal p16 positive cells

Single-cell RNA sequencing of pancreatic islets from obese mice with different diabetes risk reveals diabetes-susceptible β cell clusters

Activity-dependent modulation of synapse-regulating genes in astrocytes

Single-cell RNA sequencing reveals a role of Phf2 in promoting the exit of postnatal neural stem cell from shallow quiescence.

Partial reprogramming restores youthful gene expression through transient suppression of cell identity

Reconstruction of dynamic regulatory networks reveals signaling-induced topology changes associated with germ layer specification

Heme-Nrf2 signaling shifts myeloid differentiation

Heme signaling shifts myeloid differentiation in GM-CSF BM cell cultures

Heme exposure shifts shifts myeloid differentiation in bone marrow derived mixed cell cultures.

Deviated myeloid differentiation in SCD mice under heme stress I.

Deviated myeloid differentiation in SCD mice under heme stress II.

Heme-activated Nrf2 signaling skews fate trajectories of bone marrow cells from dendritic cells towards macrophages

Single Cell RNA Sequencing reveals heterogenous tumor associated immune cell compartment in lean vs obese mice using an MC38 tumor model

Arthritogenic SKG T cells have a transcriptional program of activation and a repertoire pruned by superantigen

Reversal of lineage plasticity in RB1/TP53-deleted prostate cancer through FGFR and Janus kinase inhibition

Single cell RNA-sequencing of pleural cavity macrophages naïve and nematode-infected C57BL/6 and BALB/c mice

Cancer cell non-autonomous tumor progression from chromosomal instability