Transcriptional and epigenetic landscape of the mouse intestine during aging identifies key molecular drivers of aging -associated dysfunctions and diseases. [Total RNA-seq - Lgr5]

Transcriptional and epigenetic landscape of the mouse intestine during aging identifies key molecular drivers of aging -associated dysfunctions and diseases [Total RNA-seq - crypts]

Transcriptional and epigenetic landscape of the mouse intestine during aging identifies key molecular drivers of aging -associated dysfunctions and diseases [scRNA-seq].

HAT cofactor TRRAP modulates microtubule dynamics via SP1 signaling to prevent neurodegeneration

Altered regional progenitor dynamics in the neocortex of a BBSOA disease mouse model

Identification of dormant cells using a novel fluorescent reporter of RNA-polymerase II activity

Stat1 activation, through systemic interferon signaling, and upregulation of innate immune system receptors drives inflammaging, that is ameliorated by dietary restriction intervention [ATAC-seq]

Stat1 activation, through systemic interferon signaling, and upregulation of innate immune system receptors drives inflammaging, that is ameliorated by dietary restriction intervention [RNA-seq]

Atlas of the aging mouse colon

Atlas of the aging mouse intestine

Characteristic evaluation of in vitro 3D cell culture model in a multi-dimensional way with high-throughput sequencing

In vitro grown organoids treated with IFNγ mimicking in vivo intestinal crypts cells aging