WT, scRNAseq

Opa1cKO, scRNAseq

calvaria of tumor-free control mice

tumor-excised calvarial tissues from the scratch-negative (pre-invasive stage) group

tumor-excised calvarial tissues from the scratch-positive (invasive stage) group

Ptf1aERT, 2 weeks, replicate 1

Ptf1aERT, 2 weeks, replicate 2

Ptf1aERT;K*, 2 weeks, replicate 1

Ptf1aERT;K*, 2 weeks, replicate 2

Ptf1aERT;Pdx1f/f, 2 weeks, replicate 1

Ptf1aERT;Pdx1f/f, 2 weeks, replicate 2

Ptf1aERT;K*;Pdx1f/f, 2 weeks, replicate 1

Ptf1aERT;K*;Pdx1f/f, 2 weeks, replicate 2

Ptf1aERT;K*, 10 weeks, replicate 1

Ptf1aERT;K*, 10 weeks, replicate 2

Ptf1aERT;K*;Pdx1f/f, 10 weeks, replicate 1

Ptf1aERT;K*;Pdx1f/f, 10 weeks, replicate 2

WT β cells, 2.8mM G, rep 1

WT β cells, 2.8mM G, rep 2

WT β cells, 2.8mM G, rep 3