Genome

Fusobacterium nucleatum Normal oral and gastrointestinal bacterium Lineage: Bacteria[37515]; Fusobacteriota[80]; Fusobacteriia[77]; Fusobacteriales[70]; Fusobacteriaceae[42]; Fusobacterium[24]; Fusobacterium nucleatum[1]

Fusobacterium. This genus contains mostly obligately anaerobic bacilli. Some of them are motile, some are non-motile. They inhabit mucous membranes of humans and animals. Many of the isolates are spindle-shaped, or fusiform. However, there are also rods with parallel walls, but rounded or tapered ends. Fusobacterium nucleatum More.... This organism belongs to the normal microflora of the human oral and gastrointestinal tracts. It is a very long and slender spindle-shaped bacillus with sharply pointed ends that is characterized by the ability to invade soft tissues. Although not considered a major dental pathogen on its own, this anaerobe facilitates the aggregation and establishment of several other species including the dental pathogens Porphyromonas gingivalis and Bacteroides forsythus. The bacterium is capable of forming coaggregates with other pathogenic and non-pathogenic bacteria. It acts as a bridge between early and late colonizers of the tooth surface, and exerts synergism with other bacteria in mixed infections. It is most frequently associated with periodontal diseases, as well as with some invasive human infections of the head and neck, chest, lung, liver and abdomen, and some anginas. One of the major amino acid and sugar fermentation pathways in Fusobacterium nucleatum produces butyric and acetic acids. Production of butyrate has several consequences: mouth odor and decay of teeth, and inhibition of fibroblast proliferation, which prevents healing of wounds in the gum. Less...

Summary Sequence data:  genome assemblies: 98  (See  Genome Assembly and Annotation report) Statistics:  median total length (Mb): 2.16212  median protein count: 1976  median GC%: 27.1 Publications (limited to 20 most recent records) A distinct Fusobacterium nucleatum clade dominates the colorectal cancer niche. Zepeda-Rivera M, et al. Nature 2024 Apr In Vivo Generation of BK and JC Polyomavirus Defective Viral Genomes in Human Urine Samples Associated with Higher Viral Loads. Addetia A, et al. J Virol 2021 May 24 Genome Investigation of Urinary Gardnerella Strains and Their Relationship to Isolates of the Vaginal Microbiota. Putonti C, et al. mSphere 2021 May 12 Comparative Analysis of Colon Cancer-Derived Fusobacterium nucleatum Subspecies: Inflammation and Colon Tumorigenesis in Murine Models. Queen J, et al. mBio 2021 Feb 22 MGnify: the microbiome analysis resource in 2020. Mitchell AL, et al. Nucleic Acids Res 2020 Jan 8 Aerococcus urinae Isolated from Women with Lower Urinary Tract Symptoms: In Vitro Aggregation and Genome Analysis. Hilt EE, et al. J Bacteriol 2020 Jun 9 Viral Genetics Modulate Orolabial Herpes Simplex Virus Type 1 Shedding in Humans. Ramchandani MS, et al. J Infect Dis 2019 Mar 15 Mycobacterium talmoniae, a Potential Pulmonary Pathogen Isolated from Multiple Patients with Bronchiectasis in the United States, Including the First Case of Clinical Disease in a Patient with Cystic Fibrosis. Vasireddy R, et al. J Clin Microbiol 2019 Feb Prospective, Real-time Metagenomic Sequencing During Norovirus Outbreak Reveals Discrete Transmission Clusters. Casto AM, et al. Clin Infect Dis 2019 Aug 30 VAPiD: a lightweight cross-platform viral annotation pipeline and identification tool to facilitate virus genome submissions to NCBI GenBank. Shean RC, et al. BMC Bioinformatics 2019 Jan 23 Systematic evasion of the restriction-modification barrier in bacteria. Johnston CD, et al. Proc Natl Acad Sci U S A 2019 Jun 4 EBI Metagenomics in 2017: enriching the analysis of microbial communities, from sequence reads to assemblies. Mitchell AL, et al. Nucleic Acids Res 2018 Jan 4 Comparative genomic, transcriptomic, and proteomic reannotation of human herpesvirus 6. Greninger AL, et al. BMC Genomics 2018 Mar 20 Heterogeneous Antimicrobial Susceptibility Characteristics in Pseudomonas aeruginosa Isolates from Cystic Fibrosis Patients. Qin X, et al. mSphere 2018 Mar-Apr The human clone ST22 SCCmec IV methicillin-resistant Staphylococcus aureus isolated from swine herds and wild primates in Nepal: is man the common source? Roberts MC, et al. FEMS Microbiol Ecol 2018 May 1 Ultrasensitive Capture of Human Herpes Simplex Virus Genomes Directly from Clinical Samples Reveals Extraordinarily Limited Evolution in Cell Culture. Greninger AL, et al. mSphere 2018 Jun 27 Viral Entry Properties Required for Fitness in Humans Are Lost through Rapid Genomic Change during Viral Isolation. Iketani S, et al. mBio 2018 Jul 3 Limited Marginal Utility of Deep Sequencing for HIV Drug Resistance Testing in the Age of Integrase Inhibitors. Dalmat RR, et al. J Clin Microbiol 2018 Dec Conservation and Recombination in the Genome Sequence of Haemophilus influenzae Type f WAPHL1. Bateman AC, et al. Genome Announc 2017 Sep 21 Dual-strain genital herpes simplex virus type 2 (HSV-2) infection in the US, Peru, and 8 countries in sub-Saharan Africa: A nested cross-sectional viral genotyping study. Johnston C, et al. PLoS Med 2017 Dec More...  Representative (genome information for reference and representative genomes) Reference genome:   Fusobacterium nucleatum subsp. nucleatum ATCC 25586 Human Pathogen Type Name RefSeq INSDC Size (Mb) GC% Protein rRNA tRNA Other RNA Gene Pseudogene Chr - NZ_CP028101.1 CP028101.1 2.18 27.1 1,964 15 47 3 2,065 36 Dendrogram (based on genomic BLAST)