Genome

Acinetobacter baumannii Causes opportunistic infections in hospitals Lineage: Bacteria[37515]; Pseudomonadota[11108]; Gammaproteobacteria[4595]; Moraxellales[188]; Moraxellaceae[188]; Acinetobacter[98]; Acinetobacter calcoaceticus/baumannii complex[8]; Acinetobacter baumannii[1]

Acinetobacter baumannii.This bacterium is commonly isolated from the hospital environment and hospitalized patients. It is an aquatic organism, and is often cultured from liquid medical samples such as respiratory secretions, wounds, and urine. Acinetobacter also colonizes irrigating solutions and intravenous solutions. Although More...it has low virulence, it is capable of causing infection. Most isolates recovered from patients represent colonization rather than infection. When infections do occur, they usually occur in the blood, or in organs with a high fluid content, such as the lungs or urinary tract.Infections by this organism are becoming increasingly problematic due to the high number of resistance genes found in clinical isolates. Some strains are now resistant to all known antibiotics. Most of these genes appear to have been transferred horizontally from other organisms. Many of them cluster into a single genomic island in strain AYE as compared to strain SDF. Less...

Summary Sequence data:  genome assemblies: 9209; sequence reads: 27  (See  Genome Assembly and Annotation report) Statistics:  median total length (Mb): 3.9654  median protein count: 3686  median GC%: 39 Publications (limited to 20 most recent records) MuDoGeR: Multi-Domain Genome recovery from metagenomes made easy. Rocha U, et al. Mol Ecol Resour 2024 Feb Evolutionary trends of carbapenem-resistant and susceptible Acinetobacter baumannii isolates in a major tertiary care setting from North India. Bansal K, et al. Infect Genet Evol 2024 Jan Bacterial and Candida Colonization of Neonates in a Regional Hospital in South Africa. Mabena FC, et al. Pediatr Infect Dis J 2024 Mar 1 Genomic Surveillance Uncovers a 10-Year Persistence of an OXA-24/40 Acinetobacter baumannii Clone in a Tertiary Hospital in Northern Spain. Aranzamendi M, et al. Int J Mol Sci 2024 Feb 16 Phylogenomic and phenotypic analyses highlight the diversity of antibiotic resistance and virulence in both human and non-human Acinetobacter baumannii. Sykes EME, et al. mSphere 2024 Mar 26 Genotypic and phenotypic mechanisms underlying antimicrobial resistance and synergistic efficacy of rifampicin-based combinations against carbapenem-resistant Acinetobacter baumannii. Nwabor LC, et al. Heliyon 2024 Mar 30 Acinetobacter baumannii international clone 2 co-producing OXA-23, NDM-1, and ArmA emerging in South America. Martins-Gonçalves T, et al. Antimicrob Agents Chemother 2024 May 2 Comparative genomics and molecular epidemiology of colistin-resistant Acinetobacter baumannii. Kabic J, et al. Comput Struct Biotechnol J 2023 Metagenome-assembled genomes indicate that antimicrobial resistance genes are highly prevalent among urban bacteria and multidrug and glycopeptide resistances are ubiquitous in most taxa. Magnúsdóttir S, et al. Front Microbiol 2023 Horizontal Gene Transfer, Fitness Costs and Mobility Shape the Spread of Antibiotic Resistance Genes into Experimental Populations of Acinetobacter Baylyi. Sezmis AL, et al. Mol Biol Evol 2023 Mar 4 A neglected and emerging antimicrobial resistance gene encodes for a serine-dependent macrolide esterase. Dhindwal P, et al. Proc Natl Acad Sci U S A 2023 Feb 21 Emergence and Evolution of OXA-23-Producing ST46(Pas)-ST462(Oxf)-KL28-OCL1 Carbapenem-Resistant Acinetobacter baumannii Mediated by a Novel ISAba1-Based Tn7534 Transposon. Liu H, et al. Antibiotics (Basel) 2023 Feb 16 Insights into the genetic contexts of sulfonamide resistance among early clinical isolates of Acinetobacter baumannii. Bala A, et al. Infect Genet Evol 2023 Aug Genomic dissection of endemic carbapenem resistance reveals metallo-beta-lactamase dissemination through clonal, plasmid and integron transfer. Macesic N, et al. Nat Commun 2023 Aug 8 Co-Existence of bla(NDM-1), bla(OXA-23), bla(OXA-64), bla(PER-7) and bla(ADC-57) in a Clinical Isolate of Acinetobacter baumannii from Alexandria, Egypt. Sánchez-Urtaza S, et al. Int J Mol Sci 2023 Aug 7 Healthcare Equipment and Personnel Reservoirs of Carbapenem-Resistant Acinetobacter baumannii Epidemic Clones in Intensive Care Units in a Tunisian Hospital. Azaiez S, et al. Microorganisms 2023 Oct 26 The StkSR Two-Component System Influences Colistin Resistance in Acinetobacter baumannii. Giles SK, et al. Microorganisms 2022 May 8 Strain-level profiling with picodroplet microfluidic cultivation reveals host-specific adaption of honeybee gut symbionts. Meng Y, et al. Microbiome 2022 Aug 31 Mining of novel secondary metabolite biosynthetic gene clusters from acid mine drainage. Wang L, et al. Sci Data 2022 Dec 9 Diversity of resistant determinants, virulence factors, and mobile genetic elements in Acinetobacter baumannii from India: A comprehensive in silico genome analysis. Kumkar SN, et al. Front Cell Infect Microbiol 2022 More...  Representative (genome information for reference and representative genomes) Reference genome:   Acinetobacter baumannii ASM863263v1 Type Name RefSeq INSDC Size (Mb) GC% Protein rRNA tRNA Other RNA Gene Pseudogene Chr - NZ_CP043953.1 CP043953.1 3.97 39.0 3,581 18 72 4 3,720 45 Plsm pK09-14 NZ_CP043954.1 CP043954.1 0.01 33.7 11 - - - 11 - Dendrogram (based on genomic BLAST)