Genome

Mucor circinelloides Model system for studying light response regulation Lineage: Eukaryota[15558]; Fungi[5219]; Fungi incertae sedis[363]; Mucoromycota[182]; Mucoromycotina[99]; Mucoromycetes[89]; Mucorales[89]; Mucorineae[51]; Mucoraceae[26]; Mucor[12]; Mucor circinelloides[1]

Serves as a model system for studying light response regulation but is also an emerging opportunistic pathogen in immunocomprimised patients. The fungus is dimorphic thus it grows as a budding yeast anaerobically and as a filamentous fungus aerobically and is in the same family (Mucoraceae More...) as Rhizopus oryzae, which is the most common causal agent of mucormycosis. In M. circinelloides it has been shown that a sporangiospore size dimorphism is linked to virulence. Using the wax moth as host, it has been shown that M. circinelloides f. lusitanicus (-) mating type isolates produce larger asexual sporangiospores that are more virulent compared to (+) isolates that produce smaller less virulent sporangiospores.The Rhizopus oryzae genome has features of a whole-genome duplication and a comparative genome analysis of M. circinelloides with R. oryzae and P. blakesleeanus also indicated the presences of loosely conserved duplicated regions.The genome is approximately 37Mb and karyotypes are markedly different between forma. Less...

Summary Sequence data:  genome assemblies: 17; sequence reads: 18  (See  Genome Assembly and Annotation report) Statistics:  median total length (Mb): 33.4459  median protein count: 12227  median GC%: 39.2 Publications (limited to 20 most recent records) Complete Genome Sequence of a High Lipid-Producing Strain of Mucor circinelloides WJ11 and Comparative Genome Analysis with a Low Lipid-Producing Strain CBS 277.49. Tang X, et al. PLoS One 2015 Analysis of a food-borne fungal pathogen outbreak: virulence and genome of a Mucor circinelloides isolate from yogurt. Lee SC, et al. mBio 2014 Jul 8  Representative (genome information for reference and representative genomes) Reference genome:   Mucor circinelloides ASM3797494v1 Submitter: Faculty of Veterinary Medicine, University of Lisbon Loc Type Name RefSeq INSDC Size (Mb) GC% master WGS - JBBNAA000000000.1 40.88 39.1 Chromosomes