Genome

Aedes aegypti (yellow fever mosquito) The mosquito vector for dengue and yellow fever Lineage: Eukaryota[15557]; Metazoa[7782]; Ecdysozoa[3517]; Arthropoda[3303]; Hexapoda[2975]; Insecta[2841]; Pterygota[2839]; Neoptera[2820]; Endopterygota[2630]; Diptera[678]; Nematocera[113]; Culicoidea[57]; Culicidae[55]; Culicinae[13]; Aedini[6]; Aedes[4]; Stegomyia[2]; Aedes aegypti[1]

Dengue and yellow fever are transmitted by Aedes aegypti, also known as the yellow fever mosquito. Dengue is an acute viral disease prevalent in most tropical urban areas of the world. A small percentage of people contracting dengue develop the more severe form of the disease, dengue hemorrhagic fever/dengue shock syndrome. A. aegypti More...was the first arthropod identified as a vector involved in transmission of a viral disease, thereby playing an important role in the institution of vector control.Genetic and physical mapping techniques have been applied to define and compare genome organization and structure among and within mosquito species. The genome-based analysis of several mosquitos are in progress, including A. aegypti. The first DNA-based, complete mosquito genetic map was constructed for A. aegypti. In addition, a low resolution physical map has been generated, based upon chromosome microdissection and in situ hybridization to polytene chromosomes. Further genome-scale studies will contribute to our understanding of mosquito biology, vector competence and mosquito control. Less...

Summary Sequence data:  genome assemblies: 8; sequence reads: 11  (See  Genome Assembly and Annotation report) Statistics:  median total length (Mb): 1278.68  median protein count: 22858  median GC%: 38.1667 NCBI Annotation Release:  101 Publications (limited to 20 most recent records) A chromosome-level assembly of the widely used Rockefeller strain of Aedes aegypti, the yellow fever mosquito. Fisher CR, et al. G3 (Bethesda) 2022 Nov 4 Improved reference genome of Aedes aegypti informs arbovirus vector control. Matthews BJ, et al. Nature 2018 Nov The Diversity, Structure, and Function of Heritable Adaptive Immunity Sequences in the Aedes aegypti Genome. Whitfield ZJ, et al. Curr Biol 2017 Nov 20 The neurotranscriptome of the Aedes aegypti mosquito. Matthews BJ, et al. BMC Genomics 2016 Jan 6 Numerous transitions of sex chromosomes in Diptera. Vicoso B, et al. PLoS Biol 2015 Apr Genome sequence of Aedes aegypti, a major arbovirus vector. Nene V, et al. Science 2007 Jun 22 More...  Representative (genome information for reference and representative genomes) Reference genome:   Aedes aegypti AaegL5.0 Submitter: Aedes aegypti Genome Working Group (AGWG) Loc Type Name RefSeq INSDC Size (Mb) GC% Protein rRNA tRNA Other RNA Gene Pseudogene Chr 1 NC_035107.1 CM008043.1 310.83 38.6 6,243 - 208 1,217 4,381 60 Chr 2 NC_035108.1 CM008044.1 474.43 37.9 11,142 - 351 1,631 7,160 82 Chr 3 NC_035109.1 CM008045.1 409.78 38.1 9,679 - 299 1,451 6,493 102 MT NC_035159.1 MF194022.1 0.02 21.0 13 2 23 - 38 - Un - . - 83.68 38.4 1,240 - 52 410 1,551 138 Chromosomes Click on chromosome name to open Genome Data Viewer External Resources DFCI A.aegypti Gene Index AaeDB Aedes Aegypti Genome Project (Notre Dame) Aedes aegypti genome Sequencing AnoBase Broad Institute Dengue Fever (CDC) Microbial Sequencing Center (TIGR) Mosquito Genomics OrthoDB TIGR Aedes aegypti Genome Project VectorBase