Genome

Neurospora crassa A filamentous saprophyte that is one of the most intensively studied in genetic and biochemical research Lineage: Eukaryota[15557]; Fungi[5220]; Dikarya[4853]; Ascomycota[3867]; Pezizomycotina[2638]; Sordariomycetes[1176]; Sordariomycetidae[272]; Sordariales[107]; Sordariaceae[39]; Neurospora[33]; Neurospora crassa[1]

The Neurospora crassa genome is approximately 40 Mb, organized in 7 chromosomes and linkage group to chromosome assignments have been confirmed: I = 1; II = 6; III = 3; IV = 4; V = 2; VI = 5; VII = 7. Studies on this model organism led to the classical concept of "one gene, one enzyme". Beadle and Tatum received the Nobel Prize for Medicine/Physiology More...in 1958 for their landmark Neurospora work in 1941.Neurospora crassa is a haploid, heterothallic ascomycete and analysis of genetic recombination is facilitated by the ordered arrangement of the products of meiosis in the ascospores. N. crassa perceives light only in the blue/UV range and shows a pronounced circadian rhythm which makes it a preferred model organism for investigating light perception. It is also known for studies investigating epigenetics, gene silencing, cell polarity and cell fusion.N. crassa has a very effective mechanism of genome defense termed repeat-induced point mutation (RIP). The process detect gene duplications at the haploid dikaryotic phase of the sexual cycle and mutates both copies of a duplicated gene by causing numerous mutations from G-C to A-T pairs. Thereby eliminating intact mobile elements. Less...

Summary Sequence data:  genome assemblies: 7; sequence reads: 981  (See  Genome Assembly and Annotation report) Statistics:  median total length (Mb): 40.4162  median protein count: 11390  median GC%: 48.9 Publications (limited to 20 most recent records) Genome-scale phylogeny and comparative genomics of the fungal order Sordariales. Hensen N, et al. Mol Phylogenet Evol 2023 Dec Draft Genome Sequence of Neurospora crassa Strain FGSC 73. Baker SE, et al. Genome Announc 2015 Apr 2 ALLPATHS 2: small genomes assembled accurately and with high continuity from short paired reads. Maccallum I, et al. Genome Biol 2009 The genome sequence of the filamentous fungus Neurospora crassa. Galagan JE, et al. Nature 2003 Apr 24 More...  Representative (genome information for reference and representative genomes) Reference genome:   Neurospora crassa OR74A Submitter: Broad Institute Environment: Habitat:Terrestrial Loc Type Name RefSeq INSDC Size (Mb) GC% Protein rRNA tRNA Other RNA Gene Pseudogene group I NC_026501.1 CM002236.1 9.8 48.8 2,637 6 72 52 2,477 2 group II NC_026502.1 CM002237.1 4.48 48.2 1,134 22 36 14 1,100 - group III NC_026503.1 CM002238.1 5.27 48.8 1,399 9 39 23 1,325 1 group IV NC_026504.1 CM002239.1 6 48.5 1,620 14 76 19 1,594 8 group V NC_026505.1 CM002240.1 6.44 48.9 1,754 17 64 33 1,694 2 group VI NC_026506.1 CM002241.1 4.22 48.3 1,076 5 56 19 1,068 1 group VII NC_026507.1 CM002242.1 4.26 47.7 1,164 4 72 16 1,139 2 MT NC_026614.1 KC683708.1 0.06 36.1 28 - 28 - 58 2 Un - . - 0.57 28.1 - 135 - - 135 - Chromosomes Click on chromosome name to open Genome Data Viewer External Resources MIPS Neurospora crassa Genome Database DFCI N. crassa Gene Index Fungal Genetics Stock Center Tree of Life: Fungi Model Organism for Biomedical Research