Neisseria meningitidis. The second of two pathogenic
Neisseria, this organism causes septicemia and is the leading cause of life-threatening meningitis (inflammation of the meninges, the membrane surrounding the brain and spinal cord) in children. This organism typically residies in the nasopharynx cavity but can invade the respiratory
More...epthelial barrier, cross into the bloodstream and the blood brain barrier, and cause inflammation of the meninges. The antiphagocytic capsular polysaccharide (CPS) aids in virulence. There are 5 serogroups based on CPS typing (A, B, C, Y, and W135). Serogroup B results in sporadic outbreaks in Europe and North America, and there is no vaccine currently. The use of a vaccine is hindered by the fact that the serogroup B capsular polysaccharide vaccine recognizes a common human carbohydrate, and vaccines against the surface proteins suffer due to the antigenic variability of those proteins. Pathogenicity factors include the surface proteins (porins and opacity proteins), and the type IV pilus (which is also found in Neisseria gonorrhoeae). The CPS is different in Neisseria gonorrhoeae as compared to Neisseria meningitidis and the CPS from Neisseria gonorrhoeae is not antiphagocytic. The type IV pilin subunit exhibits antigenic diversity through a cassette mechanism. There are 8 silent copies of the pilin gene in the chromosome, and these are recombined to create sequence differences which result in antigenic differences. Many virulence genes, especially those that code for cell surface proteins, contain homopolymeric tracts, which are sequences of high mutability. Slippage of the DNA replication machinery at these tracts results in mutation and potentially in antigenic variation. This organism, like Neisseria gonorrhoeae, is naturally competent, and protein complexes at the cell surface recognize the uptake signal sequence in extracellular DNA, an 8mer that is found at high frequency in Neisseria chromosomal DNA. Less...- Genomic Characterization of Emerging Bacterial Uropathogen Neisseria meningitidis, Which Was Misidentified as Neisseria gonorrhoeae by Nucleic Acid Amplification Testing. Sukhum KV, et al. J Clin Microbiol 2021 Jan 21
- Host Range Determinants of Pseudomonas savastanoi Pathovars of Woody Hosts Revealed by Comparative Genomics and Cross-Pathogenicity Tests. Moreno-Pérez A, et al. Front Plant Sci 2020
- Whole-Genome Sequencing for Characterization of Capsule Locus and Prediction of Serogroup of Invasive Meningococcal Isolates. Marjuki H, et al. J Clin Microbiol 2019 Mar
- Whole-genome sequencing and characterization of an antibiotic resistant Neisseria meningitidis B isolate from a military unit in Vietnam. Tran TX, et al. Ann Clin Microbiol Antimicrob 2019 May 6
- The molecular characteristics of Neisseria meningitidis serogroup Y clonal complex 23 first emerge in China. Li B, et al. J Infect 2019 Dec
- FDA-ARGOS is a database with public quality-controlled reference genomes for diagnostic use and regulatory science. Sichtig H, et al. Nat Commun 2019 Jul 25
- BMScan: using whole genome similarity to rapidly and accurately identify bacterial meningitis causing species. Topaz N, et al. BMC Infect Dis 2018 Aug 15
- Neisseria meningitidis ST11 Complex Isolates Associated with Nongonococcal Urethritis, Indiana, USA, 2015-2016. Toh E, et al. Emerg Infect Dis 2017 Feb
- The invasive Neisseria meningitidis MenC CC103 from Brazil is characterized by an accessory gene repertoire. Marin MA, et al. Sci Rep 2017 May 9
- Increased Risk for Meningococcal Disease Among Men Who Have Sex With Men in the United States, 2012-2015. Folaranmi TA, et al. Clin Infect Dis 2017 Sep 1
- Genomic Characterization of Urethritis-Associated Neisseria meningitidis Shows that a Wide Range of N. meningitidis Strains Can Cause Urethritis. Ma KC, et al. J Clin Microbiol 2017 Dec
- Specificity of the ModA11, ModA12 and ModD1 epigenetic regulator N(6)-adenine DNA methyltransferases of Neisseria meningitidis. Seib KL, et al. Nucleic Acids Res 2015 Apr 30
- Sequence Type 4821 Clonal Complex Serogroup B Neisseria meningitidis in China, 1978-2013. Zhu B, et al. Emerg Infect Dis 2015 Jun
- Phylogenetic study of clonal complex (CC)198 capsule null locus (cnl) genomes: A distinctive group within the species Neisseria meningitidis. Xu Z, et al. Infect Genet Evol 2015 Aug
- Complete Genome Sequence of Neisseria meningitidis Serogroup A Strain NMA510612, Isolated from a Patient with Bacterial Meningitis in China. Zhang Y, et al. Genome Announc 2014 May 8
- Meningitis caused by a lipopolysaccharide deficient Neisseria meningitidis. Piet JR, et al. J Infect 2014 Oct
- Emergence of a new epidemic Neisseria meningitidis serogroup A Clone in the African meningitis belt: high-resolution picture of genomic changes that mediate immune evasion. Lamelas A, et al. mBio 2014 Oct 21
- Draft Genome Sequence of C:P1.5-1,10-8:F3-6:ST-11 Meningococcal Clinical Isolate Associated with a Cluster on a Cruise Ship. Neri A, et al. Genome Announc 2014 Dec 4
- Homologous recombination drives both sequence diversity and gene content variation in Neisseria meningitidis. Kong Y, et al. Genome Biol Evol 2013
- Draft Genome Sequence of a Neisseria meningitidis Serogroup C Isolate of Sequence Type 11 Linked to an Outbreak among Men Who Have Sex with Men. Veyrier FJ, et al. Genome Announc 2013 Oct 3
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Reference genome:  
Neisseria meningitidis ASM833080v1
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