Genome

Staphylococcus aureus Causes skin infections Lineage: Bacteria[37515]; Bacillota[6135]; Bacilli[2619]; Bacillales[1727]; Staphylococcaceae[121]; Staphylococcus[66]; Staphylococcus aureus[1]

Straphylococci. The genus Staphylococcus are pathogens of humans and other mammals. Traditionally they were divided into two groups based on the coagulase reaction. Staphylcocci are generally found inhabiting the skin and mucous membranes of mammals and birds. Some members of this genus can be found as human commensals and these are generally More...believed to have the greatest pathogenic potential in opportunistic infections. Staphylococcus aureus. This organism is a major cause of nosocomial (hospital-acquired) and community-acquired infections. Since its discovery as an opportunistic pathogen, S. aureus continues to be a major cause of mortality and is responsible for a variety of infections including, boils, furuncles, styes, impetigo and other superficial skin infections in humans. Also known to cause more serious infections particularly in the chronically ill or immunocompromised. These include pneumonia, deep abscesses, osteomyelitis, endocarditis, phlebitis, mastitis and meningitis. The ability to cause invasive disease is associated with persistance in the nasal cavity of a host. Less...

Summary Sequence data:  genome assemblies: 16858; sequence reads: 197  (See  Genome Assembly and Annotation report) Statistics:  median total length (Mb): 2.82782  median protein count: 2672  median GC%: 32.7 Publications (limited to 20 most recent records) Clinical, microbiological and genomic characterization of Gram-negative bacteria with dual carbapenemases as identified by rapid molecular testing. Mushtaq A, et al. JAC Antimicrob Resist 2024 Feb High prevalence of heteroresistance in Staphylococcus aureus is caused by a multitude of mutations in core genes. Heidarian S, et al. PLoS Biol 2024 Jan Molecular Characterization of Chimeric Staphylococcus aureus Strains from Waterfowl. Monecke S, et al. Microorganisms 2024 Jan 3 Molecular identification and whole genome sequence analyses of methicillin-resistant and mastitis-associated Staphylococcus aureus sequence types 6 and 2454 isolated from dairy cows. Rahman MH, et al. J Genomics 2024 Draft genome sequences of Bacillus licheniformis strains MEZBL63 and MEZBL64 harboring the lichenysin toxin operon isolated from livestock in South Africa. El Zowalaty ME, et al. Microbiol Resour Announc 2024 Mar 12 Prevalence of virulence- and antibiotic resistance-associated genotypes and phenotypes in Staphylococcus aureus strains from the food sector compared to clinical and cow mastitis isolates. Jurado A, et al. Front Cell Infect Microbiol 2024 Emergence and clonal expansion of a qacA-harbouring sequence type 45 lineage of methicillin-resistant Staphylococcus aureus. Nong Y, et al. Commun Biol 2024 Mar 21 Cataloging the phylogenetic diversity of human bladder bacterial isolates. Du J, et al. Genome Biol 2024 Mar 21 Emergence and spread of a mupirocin-resistant variant of the European epidemic fusidic acid-resistant impetigo clone of Staphylococcus aureus, Belgium, 2013 to 2023. Yin N, et al. Euro Surveill 2024 May Draft genome sequences of clinical mastitis-associated Enterococcus faecalis and Enterococcus faecium carrying multiple antimicrobial resistance genes isolated from dairy cows. Rahman MH, et al. J Glob Antimicrob Resist 2024 May 23 Characterisation of Methicillin-Resistant Staphylococcus aureus from Alexandria, Egypt. Monecke S, et al. Antibiotics (Basel) 2023 Jan 1 Transcriptome and Proteome of Methicillin-Resistant Staphylococcus aureus Small-Colony Variants Reveal Changed Metabolism and Increased Immune Evasion. Liu S, et al. Microbiol Spectr 2023 Feb 14 Comparative Genomics Identifies Novel Genetic Changes Associated with Oxacillin, Vancomycin and Daptomycin Susceptibility in ST100 Methicillin-Resistant Staphylococcus aureus. Di Gregorio S, et al. Antibiotics (Basel) 2023 Feb 11 First comparative genomic characterization of the MSSA ST398 lineage detected in aquaculture and other reservoirs. Salgueiro V, et al. Front Microbiol 2023 Gut pathogen colonization precedes bloodstream infection in the neonatal intensive care unit. Schwartz DJ, et al. Sci Transl Med 2023 May 3 Up-regulation of resident chromosomal fosB gene expression: a novel mechanism of acquired fosfomycin resistance in MRSA. Aiezza N, et al. J Antimicrob Chemother 2023 Jul 5 Evaluation of Omadacycline Alone and in Combination with Rifampin against Staphylococcus aureus and Staphylococcus epidermidis in an In Vitro Pharmacokinetic/Pharmacodynamic Biofilm Model. Morrisette T, et al. Antimicrob Agents Chemother 2023 Jun 15 Polyether Ionophore Antibiotics Target Drug-Resistant Clinical Isolates, Persister Cells, and Biofilms. Wollesen M, et al. Microbiol Spectr 2023 Aug 17 Clonal Complexes Distribution of Staphylococcus aureus Isolates from Clinical Samples from the Caribbean Islands. Monecke S, et al. Antibiotics (Basel) 2023 Jun 14 Comparative analysis of genomic characteristics, virulence and fitness of community-associated Staphylococcus aureus ST121 clone causing fatal diseases in China and other CA-MRSA clones. Zhou W, et al. Virulence 2023 Dec More...  Representative (genome information for reference and representative genomes) Reference genome:   Staphylococcus aureus subsp. aureus NCTC 8325 Submitter: University of Oklahoma Health Sciences Center Human Pathogen Morphology: Gram:Positive, Shape:Cocci, Motility:No Environment: OxygenReq:Facultative, OptimumTemperature:30-37, TemperatureRange:Mesophilic, Habitat:HostAssociated Phenotype: Disease:Toxic-shock syndrome and staphylococcal scarlet fever Type Name RefSeq INSDC Size (Mb) GC% Protein rRNA tRNA Other RNA Gene Pseudogene Chr - NC_007795.1 CP000253.1 2.82 32.9 2,767 16 61 - 2,872 30 Dendrogram (based on genomic BLAST) External Resources NMPDR Staphylococcus Info