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    Abd-B Abdominal B [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 47763, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Abd-Bprovided by FlyBase
    Official Full Name
    Abdominal Bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0000015
    Locus tag
    Dmel_CG11648
    See related
    AllianceGenome:FB:FBgn0000015
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    9; Abd B; abd-B; Abd-b; ABD-B; Abd0B; abdB; Abdb; AbdB; ABDB; AbdB(CA)[[26]]; AbdB-I; AbdB-II; AbdBm; Adb-B; AdbB; bex; BX-C; CG10291; CG11648; DmAbdB; Dmel\CG11648; Droabdb; DROABDB; FAB; Fab-6; Fab-7; Fab-8; Fab6; Fab7; iab; IAB 5; iab-5; iab-6; iab-7; Iab-7; iab-8; iab5; IAB5; iab6; iab7; IAB7; iab8; IAB8; iab8.9; iab8/9; iab9; l(3)89Ed; Mc; Mcp; MCP; pH189; Sab; Tab; tuh-3; twig; Uab-5[Sab]
    Summary
    Enables DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including genital disc development; mating; and reproductive structure development. Located in nucleus and polytene chromosome band. Is expressed in several structures, including abdomen; epithelium; extended germ band embryo; parasegment; and reproductive system. Human ortholog(s) of this gene implicated in radioulnar synostosis. Orthologous to several human genes including HOXA11 (homeobox A11) and HOXD11 (homeobox D11). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See Abd-B in Genome Data Viewer
    Location:
    89E4-89E5; 3-59 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (16927212..16972236, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (12752932..12797958, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:iab8 Neighboring gene MSA micropeptide Neighboring gene long non-coding RNA:iab4 Neighboring gene mir-iab-4 stem loop Neighboring gene mir-iab-8 stem loop Neighboring gene long non-coding RNA:CR43617 Neighboring gene long non-coding RNA:CR46267 Neighboring gene Vacuolar H[+] ATPase M9.7 subunit d Neighboring gene alpha actinin 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CRISPR/Cas9 and FLP-FRT mediated regulatory dissection of the BX-C of Drosophila melanogaster. Hajirnis N, et al. Chromosome Res, 2023 Jan 31. PMID 36719476
    2. Mapping of functional elements of the Fab-6 boundary involved in the regulation of the Abd-B hox gene in Drosophila melanogaster. Postika N, et al. Sci Rep, 2021 Feb 18. PMID 33603202, Free PMC Article
    3. Female copulation song is modulated by seminal fluid. Kerwin P, et al. Nat Commun, 2020 Mar 18. PMID 32188855, Free PMC Article
    4. Disruption of the abdominal-B promoter tethering element results in a loss of long-range enhancer-directed Hox gene expression in Drosophila. Ho MC, et al. PLoS One, 2011 Jan 21. PMID 21283702, Free PMC Article
    5. Genetic control of morphogenesis - Hox induced organogenesis of the posterior spiracles. Castelli Gair Hombría J, et al. Int J Dev Biol, 2009. PMID 19247941

    See all (881) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Boundary bypass activity in the abdominal-B region of the Drosophila bithorax complex is position dependent and regulated.
      Title: Boundary bypass activity in the abdominal-B region of the Drosophila bithorax complex is position dependent and regulated.
    2. The Drosophila Fab-7 boundary modulates Abd-B gene activity by guiding an inversion of collinear chromatin organization and alternate promoter use.
      Title: The Drosophila Fab-7 boundary modulates Abd-B gene activity by guiding an inversion of collinear chromatin organization and alternate promoter use.
    3. Redundant enhancers in the iab-5 domain cooperatively activate Abd-B in the A5 and A6 abdominal segments of Drosophila.
      Title: Redundant enhancers in the iab-5 domain cooperatively activate Abd-B in the A5 and A6 abdominal segments of Drosophila.
    4. The capacity of Abdominal-B to use the sex-specific isoform of Dsx as a cofactor underlines the possibility that these two classes of protein are capable of cooperating in selection and regulation of target genes in a tissue- and sex-specific manner
      Title: The Hox gene Abdominal-B uses Doublesex(F) as a cofactor to promote neuroblast apoptosis in the Drosophila central nervous system.
    5. complete reconstitution of bypass and blocking functions
      Title: Complete reconstitution of bypass and blocking functions in a minimal artificial Fab-7 insulator from Drosophila bithorax complex.
    6. Data report that the repression of Abd-B, in cyst stem cells (CySCs) is essential for the homeostasis and cell identity maintenance in the adult Drosophila testis. Derepression of Abd-B in CySCs disrupts the proper self-renewal of both germline stem cells (GSCs) and CySCs, and leads to an excessive expansion of early stage somatic cells, which originate from both lineages.
      Title: Repression of Abd-B by Polycomb is critical for cell identity maintenance in adult Drosophila testis.
    7. iab-7 polycomb response element (PRE) functions as a component of the Fab-7 boundary. The boundary activity of the iab-7 PRE sequence depends upon a complex called the LBC, LBC is a multiprotein complex that contains at least three distinct DNA binding proteins, the GAGA factor (GAF), Clamp, and Mod(mdg4).
      Title: The bithorax complex iab-7 Polycomb response element has a novel role in the functioning of the Fab-7 chromatin boundary.
    8. analysis of blocking and bypass activities of the Fab-8 boundary in the Drosophila bithorax complex
      Title: Functional Dissection of the Blocking and Bypass Activities of the Fab-8 Boundary in the Drosophila Bithorax Complex.
    9. Abd-B is required in neurons during development for females to become highly receptive to male courtship. Abd-B neurons control pausing, a key aspect of female sexual receptivity, in response to male courtship.
      Title: Abdominal-B neurons control Drosophila virgin female receptivity.
    10. We also observed that these functions of abd-A are required in its exclusive as well as the coexpression domain with that of Abd-B
      Title: Role of abd-A and Abd-B in development of abdominal epithelia breaks posterior prevalence rule.
    Submit: New GeneRIF Correction See all GeneRIFs (36)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in determination of genital disc primordium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in external genitalia morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in female genitalia development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in genital disc anterior/posterior pattern formation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in genital disc sexually dimorphic development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in germ cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in germ cell migration TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in gonadal mesoderm development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc-derived female genitalia development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in male genitalia development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in male gonad development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in male pigmentation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in midgut development TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of cardioblast cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of female receptivity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of salivary gland boundary specification TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of striated muscle tissue development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuroendocrine cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in open tracheal system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of apoptotic process involved in morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in segment specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in specification of segmental identity, abdomen IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sperm storage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spiracle morphogenesis, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in polytene chromosome band IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    abdominal B
    Names
    Abd-B-PA
    Abd-B-PB
    Abd-B-PC
    Abd-B-PD
    Abd-B-PE
    Abd-B-PF
    Abd-B-PG
    Abd-B-PH
    Abd-B-PI
    Abd-B-PJ
    Abdominal-B
    AbdominalB
    CG11648-PA
    CG11648-PB
    CG11648-PC
    CG11648-PD
    CG11648-PE
    CG11648-PF
    CG11648-PG
    CG11648-PH
    CG11648-PI
    CG11648-PJ
    abdominal-A
    corset
    infra-abdominal 5
    infra-abdominal 6
    infra-abdominal 7
    infra-abdominal 8
    infra-abdominal 9
    infraabdominal
    infraabdominal-8.9
    male chauvinist pigmentation
    microcephalus
    miscadastral pigmentation
    superabdominal
    transabdominal

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      16927212..16972236 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_206498.2 → NP_996220.1  abdominal B, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996220.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V304
      Conserved Domains (1) summary
      pfam00046
      Location:167 → 220
      Homeobox; Homeobox domain

    2. NM_001316545.1 → NP_001303474.1  abdominal B, isoform I [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V304
      Conserved Domains (1) summary
      pfam00046
      Location:167 → 220
      Homeobox; Homeobox domain

    3. NM_001316543.1 → NP_001303472.1  abdominal B, isoform H [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P09087, Q9VEQ8, Q9VEQ9
      UniProtKB/TrEMBL
      A0A126GUV3
      Conserved Domains (1) summary
      pfam00046
      Location:390 → 443
      Homeobox; Homeobox domain

    4. NM_001316542.1 → NP_001303471.1  abdominal B, isoform J [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V304
      Conserved Domains (1) summary
      pfam00046
      Location:167 → 220
      Homeobox; Homeobox domain

    5. NM_169735.2 → NP_732180.1  abdominal B, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732180.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V304
      Related
      FBpp0082823
      Conserved Domains (1) summary
      pfam00046
      Location:167 → 220
      Homeobox; Homeobox domain

    6. NM_142320.2 → NP_650577.1  abdominal B, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650577.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V304
      Related
      FBpp0082824
      Conserved Domains (1) summary
      pfam00046
      Location:167 → 220
      Homeobox; Homeobox domain

    7. NM_169736.2 → NP_732181.1  abdominal B, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732181.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V304
      Related
      FBpp0082825
      Conserved Domains (1) summary
      pfam00046
      Location:167 → 220
      Homeobox; Homeobox domain

    8. NM_001275719.2 → NP_001262648.1  abdominal B, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262648.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KGT1
      Conserved Domains (1) summary
      pfam00046
      Location:167 → 220
      Homeobox; Homeobox domain

    9. NM_001316544.1 → NP_001303473.1  abdominal B, isoform G [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A126GUV9
      Conserved Domains (1) summary
      pfam00046
      Location:167 → 220
      Homeobox; Homeobox domain

    10. NM_080157.3 → NP_524896.2  abdominal B, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524896.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P09087, Q9VEQ8, Q9VEQ9
      UniProtKB/TrEMBL
      A0A126GUV3
      Related
      FBpp0082826
      Conserved Domains (1) summary
      pfam00046
      Location:390 → 443
      Homeobox; Homeobox domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KGT1 A0A0B4KGT1
    A0A126GUV3 A0A126GUV3
    A0A126GUV9 A0A126GUV9
    A4V304 A4V304
    P09087.3 P09087
    Q86P38 Q86P38
    Q9VEQ7 Q9VEQ7
    V9H1H6 V9H1H6

    Gene LinkOut

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