tomt transmembrane O-methyltransferase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tomtprovided by ZNC
Official Full Name: transmembrane O-methyltransferaseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-160629-1
See related: Ensembl:ENSDARG00000115463 AllianceGenome:ZFIN:ZDB-GENE-160629-1
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: mrc; mercury
Summary: Predicted to enable catechol O-methyltransferase activity. Involved in auditory behavior. Acts upstream of or within several processes, including detection of mechanical stimulus involved in sensory perception; neuromast development; and neuron differentiation. Located in Golgi apparatus; basolateral plasma membrane; and endoplasmic reticulum. Is expressed in anterior macula; inner ear; neuromast hair cell; and posterior macula. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 63. Orthologous to human LRTOMT (leucine rich transmembrane and O-methyltransferase domain containing). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 15

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	15	NC_007126.7 (47807934..47813257, complement)

Chromosome 15 - NC_007126.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_007126.7 Chromosome 15 Reference GRCz11 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The authors found that Tmc1/2 proteins are specifically excluded from the hair bundle in tomt mutants, whereas other mechanotransduction complex proteins can still localize to the bundle.
Title: Integration of Tmc1/2 into the mechanotransduction complex in zebrafish hair cells is regulated by Transmembrane O-methyltransferase (Tomt).

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables O-methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables catechol O-methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables catechol O-methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in catecholamine catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within catecholamine metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within detection of mechanical stimulus involved in sensory perception	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in developmental process	IBA Inferred from Biological aspect of Ancestor more info
involved_in dopamine metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hair cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within inner ear receptor cell stereocilium organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within methylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neuromast development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sensory perception of sound	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: transmembrane O-methyltransferase homolog; transmembrane O-methyltransferase

Names: protein mercury

XP_021322195.1

EC 2.1.1.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001424185.1 → NP_001411114.1 transmembrane O-methyltransferase homolog

Status: VALIDATED

Source sequence(s)

CZQB01095947, CZQB01095951

UniProtKB/Swiss-Prot

A0A193KX02

UniProtKB/TrEMBL

A0A8M9PLX8

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007126.7 Reference GRCz11 Primary Assembly

Range

47807934..47813257 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021466520.1 → XP_021322195.1 transmembrane O-methyltransferase

Related

ENSDARP00000145949.1, ENSDART00000190231.1

Conserved Domains (1) summary

COG4122
Location:43 → 248

YrrM; Predicted O-methyltransferase YrrM [General function prediction only]