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    LIS WD-40 repeat family protein / small nuclear ribonucleoprotein Prp4p-like protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 818748, updated on 7-Sep-2023

    Summary

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    Gene symbol
    LIS
    Gene description
    WD-40 repeat family protein / small nuclear ribonucleoprotein Prp4p-like protein
    Primary source
    Araport:AT2G41500
    Locus tag
    AT2G41500
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    EMB2776; LACHESIS; T26J13.9; T26J13_9
    Summary
    Encodes LACHESIS (LIS), a protein with seven WD40 repeats. LIS is homologous to the yeast splicing factor PRP4 which is associated with the U4/U6 complex of the spliceosome. LIS is involved in a mechanism that prevents accessory cells from adopting gametic cell fate: lis mutant forms supernumerary egg cells.
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    Genomic context

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    See LIS in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    7
    Sequence:
    Chromosome: 2; NC_003071.7 (17304130..17307426, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene Embryo-specific protein 3, (ATS3) Neighboring gene peroxidase superfamily protein Neighboring gene UDP-glcnac-adolichol phosphate glcnac-1-p-transferase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene cytokinin oxidase/dehydrogenase 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. LACHESIS-dependent egg-cell signaling regulates the development of female gametophytic cells. Völz R, et al. Development, 2012 Feb. PMID 22190635
    2. LACHESIS restricts gametic cell fate in the female gametophyte of Arabidopsis. Gross-Hardt R, et al. PLoS Biol, 2007 Mar. PMID 17326723, Free PMC Article
    3. CLO/GFA1 and ATO are novel regulators of gametic cell fate in plants. Moll C, et al. Plant J, 2008 Dec. PMID 18702672
    4. Arabidopsis DDB1-CUL4 ASSOCIATED FACTOR1 forms a nuclear E3 ubiquitin ligase with DDB1 and CUL4 that is involved in multiple plant developmental processes. Zhang Y, et al. Plant Cell, 2008 Jun. PMID 18552200, Free PMC Article
    5. A Pan-plant Protein Complex Map Reveals Deep Conservation and Novel Assemblies. McWhite CD, et al. Cell, 2020 Apr 16. PMID 32191846, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001336916.1
    NM_129713.3

    Gene Ontology Provided by TAIR

    Process Evidence Code Pubs
    acts_upstream_of_or_within cell fate determination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cell-cell signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within embryo sac development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within embryo sac egg cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Cul4-RING E3 ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    part_of spliceosomal complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    WD-40 repeat family protein / small nuclear ribonucleoprotein Prp4p-like protein
    NP_181681.1
    • LACHESIS (LIS); CONTAINS InterPro DOMAIN/s: WD40 repeat 2 (InterPro:IPR019782), WD40 repeat, conserved site (InterPro:IPR019775), Pre-mRNA processing factor 4 (PRP4) like (InterPro:IPR014906), WD40 repeat (InterPro:IPR001680), Splicing factor motif (InterPro:IPR003648), G-protein beta WD-40 repeat, region (InterPro:IPR020472), WD40 repeat-like-containing domain (InterPro:IPR011046), WD40-repeat-containing domain (InterPro:IPR017986), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), WD40 repeat, subgroup (InterPro:IPR019781); BEST Arabidopsis thaliana protein match is: Transducin/WD40 repeat-like superfamily protein (TAIR:AT2G05720.1); Has 96331 Blast hits to 36444 proteins in 930 species: Archae - 78; Bacteria - 11869; Metazoa - 38307; Fungi - 21059; Plants - 12275; Viruses - 15; Other Eukaryotes - 12728 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      17304130..17307426 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_129713.3 → NP_181681.1  WD-40 repeat family protein / small nuclear ribonucleoprotein Prp4p-like protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_181681.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O22212, Q0WNB5, Q7GAP3, Q7Y1Z3
      UniProtKB/TrEMBL
      A0A178VMW2, A0A5S9X622, A0A7G2EDD2
      Conserved Domains (3) summary
      smart00500
      Location:121 → 166
      SFM; Splicing Factor Motif, present in Prp18 and Pr04
      cd00200
      Location:257 → 535
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:258 → 296
      7WD40; WD40 repeat [structural motif]

    2. NM_001336916.1 → NP_001324961.1  WD-40 repeat family protein / small nuclear ribonucleoprotein Prp4p-like protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O22212, Q0WNB5, Q7GAP3, Q7Y1Z3
      UniProtKB/TrEMBL
      A0A178VMW2, A0A5S9X622, A0A7G2EDD2
      Conserved Domains (3) summary
      smart00500
      Location:121 → 166
      SFM; Splicing Factor Motif, present in Prp18 and Pr04
      cd00200
      Location:257 → 535
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:258 → 296
      7WD40; WD40 repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O22212.1

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