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    LEP leptin [ Capra hircus (goat) ]

    Gene ID: 100860794, updated on 8-Mar-2024

    Summary

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    Gene symbol
    LEP
    Gene description
    leptin
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Capra hircus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Capra
    Also known as
    OB; obese; hormone
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 4
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    102 current ASM170441v1 (GCF_001704415.1) 4 NC_030811.1 (27665915..27682284, complement)
    101 previous assembly CHIR_1.0 (GCF_000317765.1) 4 NC_022296.1 (89984578..89989338)

    Chromosome 4 - NC_030811.1Genomic Context describing neighboring genes Neighboring gene proline rich transmembrane protein 4 Neighboring gene RNA binding motif protein 28 Neighboring gene staphylococcal nuclease and tudor domain containing 1 Neighboring gene leucine rich repeat containing 4 Neighboring gene paired box 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The novel SNPs of leptin gene and their associations with growth traits in Chinese Nanjiang Yellow goat. Wang C, et al. Gene, 2015 Nov 1. PMID 26142105

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables hormone activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables peptide hormone receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in activation of protein kinase C activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in energy reserve metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of appetite by leptin-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of TOR signaling IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of p38MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of receptor signaling pathway via JAK-STAT IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in response to insulin IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in tyrosine phosphorylation of STAT protein IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    leptin
    Names
    Obesity factor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Capra hircus Annotation Release 102 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ASM170441v1 Primary Assembly

    Genomic

    1. NC_030811.1 Reference ASM170441v1 Primary Assembly

      Range
      27665915..27682284 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_018046968.1 → XP_017902457.1  leptin

      UniProtKB/Swiss-Prot
      Q257X2
      UniProtKB/TrEMBL
      A0A452FAM5, D4PEB4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q257X2.1 GenPept UniProtKB/Swiss-Prot:Q257X2

    Gene LinkOut

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