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    form3 formin 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 3346238, updated on 27-Feb-2024

    Summary

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    Official Symbol
    form3provided by FlyBase
    Official Full Name
    formin 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0053556
    Locus tag
    Dmel_CG33556
    See related
    AllianceGenome:FB:FBgn0053556
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    ah1644; CG14824; CG18138; CG32384; CG33556; CG8633; Dmel\CG33556; form; Form3; formin/DIA-like; Formin3; INF2
    Summary
    Predicted to enable actin binding activity. Involved in branch fusion, open tracheal system. Is expressed in presumptive embryonic/larval system; spermatozoon; and tracheocyte. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease dominant intermediate E and focal segmental glomerulosclerosis 5. Orthologous to several human genes including FHDC1 (FH2 domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    65E3-65E4; 3-19 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (7094818..7123297)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (7087918..7116397)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Cuticular protein 65Eb Neighboring gene Cuticular protein 65Ec Neighboring gene male-specific lethal 3 Neighboring gene Bardet-Biedl syndrome 1 Neighboring gene Acyl-CoA binding protein 4 Neighboring gene Acyl-CoA binding protein 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Distinct Relations of Microtubules and Actin Filaments with Dendritic Architecture. Nanda S, et al. iScience, 2020 Dec 18. PMID 33319182, Free PMC Article
    2. A Comparative Study of the Role of Formins in Drosophila Embryonic Dorsal Closure. Tóth K, et al. Cells, 2022 May 4. PMID 35563844, Free PMC Article
    3. Epistasis for head morphology in Drosophila melanogaster. Özsoy ED, et al. G3 (Bethesda), 2021 Sep 27. PMID 34568933, Free PMC Article
    4. Polyglutamine repeat proteins disrupt actin structure in Drosophila photoreceptors. Vu A, et al. Mol Cell Neurosci, 2018 Dec. PMID 30149064
    5. Formin 3 directs dendritic architecture via microtubule regulation and is required for somatosensory nociceptive behavior. Das R, et al. Development, 2021 Aug 15. PMID 34322714, Free PMC Article

    See all (58) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Formin 3 directs dendritic architecture via microtubule regulation and is required for somatosensory nociceptive behavior.
      Title: Formin 3 directs dendritic architecture via microtubule regulation and is required for somatosensory nociceptive behavior.
    2. find that Form3 has additional functions in photoreceptors, and that loss of Form3 results in the specification of extra photoreceptors in the eye
      Title: Polyglutamine repeat proteins disrupt actin structure in Drosophila photoreceptors.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in branch fusion, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular component organization IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    formin 3
    Names
    CG33556-PA
    CG33556-PB
    form3-PA
    form3-PB
    formin3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      7094818..7123297
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001104057.1 → NP_001097527.1  formin 3, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097527.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JNM1
      Conserved Domains (3) summary
      pfam02181
      Location:415 → 803
      FH2; Formin Homology 2 Domain
      pfam06367
      Location:48 → 309
      Drf_FH3; Diaphanous FH3 Domain
      pfam06371
      Location:1 → 43
      Drf_GBD; Diaphanous GTPase-binding Domain

    2. NM_001014571.1 → NP_001014571.1  formin 3, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014571.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86C16
      Conserved Domains (3) summary
      pfam02181
      Location:342 → 730
      FH2; Formin Homology 2 Domain
      pfam06367
      Location:48 → 236
      Drf_FH3; Diaphanous FH3 Domain
      pfam06371
      Location:1 → 43
      Drf_GBD; Diaphanous GTPase-binding Domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8JNM1 A8JNM1
    Q86C16 Q86C16
    Q86NV5 Q86NV5

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