U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    scml2 Scm polycomb group protein like 2 [ Xenopus tropicalis (tropical clawed frog) ]

    Gene ID: 780057, updated on 4-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    scml2provided by Xenbase
    Official Full Name
    Scm polycomb group protein like 2provided by Xenbase
    Primary source
    Xenbase:XB-GENE-6043728
    See related
    Ensembl:ENSXETG00000001116 AllianceGenome:Xenbase:XB-GENE-6043728
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Xenopus tropicalis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
    Summary
    Predicted to enable chromatin binding activity and histone binding activity. Predicted to be involved in negative regulation of DNA-templated transcription. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be active in nucleus. Orthologous to human SCML2 (Scm polycomb group protein like 2). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See scml2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    104 current UCB_Xtro_10.0 (GCF_000004195.4) 2 NC_030678.2 (95109866..95175267, complement)
    103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 2 NC_030678.1 (91289467..91355444, complement)

    Chromosome 2 - NC_030678.2Genomic Context describing neighboring genes Neighboring gene BEN domain containing 2 Neighboring gene retinoic acid induced 2 Neighboring gene SMG8 nonsense mediated mRNA decay factor Neighboring gene proline rich 11 Neighboring gene spindle and kinetochore associated complex subunit 2

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Homology

    Clone Names

    • MGC146330

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    sex comb on midleg-like protein 2
    Names
    sex comb on midleg like 2
    sex comb on midleg-like 2

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001079134.1 → NP_001072602.1  sex comb on midleg-like protein 2

      See identical proteins and their annotated locations for NP_001072602.1

      Status: PROVISIONAL

      Source sequence(s)
      BC122976
      UniProtKB/TrEMBL
      Q0IHT6
      Conserved Domains (4) summary
      cd09578
      Location:632 → 703
      SAM_Scm; SAM domain of Scm proteins of Polycomb group
      smart00454
      Location:635 → 703
      SAM; Sterile alpha motif
      smart00561
      Location:123 → 221
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
      pfam12140
      Location:350 → 459
      DUF3588; Protein of unknown function (DUF3588)

    RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference UCB_Xtro_10.0 Primary Assembly

    Genomic

    1. NC_030678.2 Reference UCB_Xtro_10.0 Primary Assembly

      Range
      95109866..95175267 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_031896132.1 → XP_031751992.1  sex comb on midleg-like protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A8J1J2C4
      Conserved Domains (4) summary
      cd09578
      Location:627 → 698
      SAM_Scm; SAM domain of Scm proteins of Polycomb group
      smart00561
      Location:123 → 221
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
      pfam12140
      Location:350 → 459
      SLED; SLED domain
      pfam17208
      Location:255 → 316
      RBR; RNA binding Region

    2. XM_012957288.3 → XP_012812742.2  sex comb on midleg-like protein 2 isoform X1

      UniProtKB/TrEMBL
      F6YNN0
      Related
      ENSXETP00000002450.5, ENSXETT00000002450.5
      Conserved Domains (4) summary
      cd09578
      Location:633 → 704
      SAM_Scm; SAM domain of Scm proteins of Polycomb group
      smart00561
      Location:123 → 221
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
      pfam12140
      Location:350 → 459
      SLED; SLED domain
      pfam17208
      Location:255 → 316
      RBR; RNA binding Region

    3. XM_012957291.3 → XP_012812745.2  sex comb on midleg-like protein 2 isoform X1

      UniProtKB/TrEMBL
      F6YNN0
      Conserved Domains (4) summary
      cd09578
      Location:633 → 704
      SAM_Scm; SAM domain of Scm proteins of Polycomb group
      smart00561
      Location:123 → 221
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
      pfam12140
      Location:350 → 459
      SLED; SLED domain
      pfam17208
      Location:255 → 316
      RBR; RNA binding Region

    4. XM_031896131.1 → XP_031751991.1  sex comb on midleg-like protein 2 isoform X1

      UniProtKB/TrEMBL
      F6YNN0
      Conserved Domains (4) summary
      cd09578
      Location:633 → 704
      SAM_Scm; SAM domain of Scm proteins of Polycomb group
      smart00561
      Location:123 → 221
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
      pfam12140
      Location:350 → 459
      SLED; SLED domain
      pfam17208
      Location:255 → 316
      RBR; RNA binding Region
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.