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    Scn7a sodium voltage-gated channel alpha subunit 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64155, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Scn7aprovided by RGD
    Official Full Name
    sodium voltage-gated channel alpha subunit 7provided by RGD
    Primary source
    RGD:61922
    See related
    EnsemblRapid:ENSRNOG00000029342 AllianceGenome:RGD:61922
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Na-G; Scn6a; SCL-11
    Summary
    Enables osmolarity-sensing monoatomic cation channel activity. Involved in sodium ion homeostasis. Predicted to be located in glial cell projection. Predicted to be part of voltage-gated sodium channel complex. Predicted to be active in plasma membrane. Biomarker of brain infarction. Orthologous to human SCN7A (sodium voltage-gated channel alpha subunit 7). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 437.9), Heart (RPKM 196.9) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Scn7a in Genome Data Viewer
    Location:
    3q21
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (71743873..71846454, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (51335841..51438308, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (52775779..52877365, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene sodium voltage-gated channel alpha subunit 1 Neighboring gene sodium voltage-gated channel alpha subunit 9 Neighboring gene histone deacetylase 1-like Neighboring gene ribosomal protein S3 like 1 Neighboring gene ribosomal protein L9, pseudogene 11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Na(X) Channel Is a Physiological [Na(+)] Detector in Oxytocin- and Vasopressin-Releasing Magnocellular Neurosecretory Cells of the Rat Supraoptic Nucleus. Salgado-Mozo S, et al. J Neurosci, 2023 Dec 6. PMID 37783507, Free PMC Article
    2. The sodium channel Na(X) : Possible player in excitation-contraction coupling. Bogdanovic E, et al. IUBMB Life, 2020 Apr. PMID 32027092
    3. Enhanced SCN7A/Nax expression contributes to bone cancer pain by increasing excitability of neurons in dorsal root ganglion. Ke CB, et al. Neuroscience, 2012 Dec 27. PMID 23026072
    4. Neuronal sodium leak channel is responsible for the detection of sodium in the rat median preoptic nucleus. Tremblay C, et al. J Neurophysiol, 2011 Feb. PMID 21084682
    5. Specific Na+ sensors are functionally expressed in a neuronal population of the median preoptic nucleus of the rat. Grob M, et al. J Neurosci, 2004 Apr 21. PMID 15102913, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NaX Channel Is a Physiological [Na[+]] Detector in Oxytocin- and Vasopressin-Releasing Magnocellular Neurosecretory Cells of the Rat Supraoptic Nucleus.
      Title: Na(X) Channel Is a Physiological [Na(+)] Detector in Oxytocin- and Vasopressin-Releasing Magnocellular Neurosecretory Cells of the Rat Supraoptic Nucleus.
    2. The sodium channel NaX : Possible player in excitation-contraction coupling.
      Title: The sodium channel Na(X) : Possible player in excitation-contraction coupling.
    3. The results of this study demonstrated that enhanced expression of SCN7A/Nax channel within distinct subpopulation of DRG neurons contributes to bone cancer pain by increasing the excitability of these neurons
      Title: Enhanced SCN7A/Nax expression contributes to bone cancer pain by increasing excitability of neurons in dorsal root ganglion.
    4. Data demonstrate predominant localisation of Na(V)1.6 and Na(V)1.7 on SGN cell bodies and Na(V)1.1 on axonal processes in rat brain.
      Title: Voltage-gated sodium channel expression in rat spiral ganglion neurons.
    5. This study shows that a neuronal population of the median preoptic nucleus acts as functional Na+ sensors and that the Na(X) channel might represent the molecular basis for the extracellular sodium level sensing in these neurons.
      Title: Specific Na+ sensors are functionally expressed in a neuronal population of the median preoptic nucleus of the rat.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables osmolarity-sensing monoatomic cation channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables osmolarity-sensing monoatomic cation channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sodium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sodium channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sodium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables sodium channel activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables transmembrane transporter binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT enables voltage-gated channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables voltage-gated sodium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT involved_in membrane depolarization during action potential IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT involved_in neuronal action potential IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in osmosensory signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in osmosensory signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within response to bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sodium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sodium ion homeostasis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within sodium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sodium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sodium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sodium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sodium ion transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in glial cell projection ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    NOT part_of voltage-gated sodium channel complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of voltage-gated sodium channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    sodium channel protein type 7 subunit alpha
    Names
    glial sodium channel alpha subunit
    nax channel
    sodium channel voltage-gated type VI alpha polypeptide
    sodium channel, voltage-gated, type 6, alpha polypeptide
    sodium channel, voltage-gated, type VII, alpha subunit
    voltage-gated sodium channel-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001388508.1 → NP_001375437.1  sodium channel protein type 7 subunit alpha

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      F1LQQ7, P97706, Q01340, Q64074
      UniProtKB/TrEMBL
      A0A8I6GH51
      Related
      ENSRNOP00000044385.5, ENSRNOT00000041096.6
      Conserved Domains (3) summary
      cd13433
      Location:1194 → 1245
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:932 → 1203
      Ion_trans; Ion transport protein
      pfam06512
      Location:742 → 926
      Na_trans_assoc; Sodium ion transport-associated

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      71743873..71846454 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039105781.2 → XP_038961709.1  sodium channel protein type 7 subunit alpha isoform X3

      UniProtKB/TrEMBL
      A0A8I6GH51
      Conserved Domains (3) summary
      cd13433
      Location:1158 → 1209
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:504 → 738
      Ion_trans; Ion transport protein
      pfam06512
      Location:742 → 926
      Na_trans_assoc; Sodium ion transport-associated

    2. XM_039105780.2 → XP_038961708.1  sodium channel protein type 7 subunit alpha isoform X2

      UniProtKB/TrEMBL
      A0A8I6GH51
      Conserved Domains (3) summary
      cd13433
      Location:1194 → 1244
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:932 → 1199
      Ion_trans; Ion transport protein
      pfam06512
      Location:742 → 926
      Na_trans_assoc; Sodium ion transport-associated

    3. XM_039105778.2 → XP_038961706.1  sodium channel protein type 7 subunit alpha isoform X1

      UniProtKB/Swiss-Prot
      F1LQQ7, P97706, Q01340, Q64074
      UniProtKB/TrEMBL
      A0A8I6GH51
      Conserved Domains (3) summary
      cd13433
      Location:1194 → 1245
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:932 → 1203
      Ion_trans; Ion transport protein
      pfam06512
      Location:742 → 926
      Na_trans_assoc; Sodium ion transport-associated

    4. XM_039105779.2 → XP_038961707.1  sodium channel protein type 7 subunit alpha isoform X1

      UniProtKB/Swiss-Prot
      F1LQQ7, P97706, Q01340, Q64074
      UniProtKB/TrEMBL
      A0A8I6GH51
      Conserved Domains (3) summary
      cd13433
      Location:1194 → 1245
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:932 → 1203
      Ion_trans; Ion transport protein
      pfam06512
      Location:742 → 926
      Na_trans_assoc; Sodium ion transport-associated

    5. XM_063284500.1 → XP_063140570.1  sodium channel protein type 7 subunit alpha isoform X1

      UniProtKB/Swiss-Prot
      F1LQQ7, P97706, Q01340, Q64074

    6. XM_063284501.1 → XP_063140571.1  sodium channel protein type 7 subunit alpha isoform X4

    7. XM_063284502.1 → XP_063140572.1  sodium channel protein type 7 subunit alpha isoform X5

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_031686.1: Suppressed sequence

      Description
      NM_031686.1: This RefSeq was removed because there is insufficient support for the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F1LQQ7.4 GenPept UniProtKB/Swiss-Prot:F1LQQ7

    Gene LinkOut

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