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    TGFA transforming growth factor alpha [ Sus scrofa (pig) ]

    Gene ID: 397484, updated on 17-Aug-2024

    Summary

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    Official Symbol
    TGFAprovided by VGNC
    Official Full Name
    transforming growth factor alphaprovided by VGNC
    Primary source
    VGNC:VGNC:93928
    See related
    Ensembl:ENSSSCG00000008326
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
    Expression
    Biased expression in spleen (RPKM 4.1), ovary (RPKM 2.8) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See TGFA in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) 3 NC_010445.4 (71948232..72054257)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) 3 NC_010445.3 (75409715..75437890, complement)

    Chromosome 3 - NC_010445.4Genomic Context describing neighboring genes Neighboring gene folliculogenesis specific bHLH transcription factor Neighboring gene adducin 2 Neighboring gene uncharacterized LOC110259992 Neighboring gene uncharacterized LOC110260138 Neighboring gene family with sequence similarity 136 member A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
    • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
    • BioProject: PRJNA311523
    • Publication: PMID 27646534
    • Analysis date: Thu Dec 14 17:10:49 2017

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and tissue distribution of pig transforming growth factor alpha. Vaughan TJ, et al. Biochem J, 1993 Dec 15. PMID 8280083, Free PMC Article
    2. Expression of FGF2 and TGFalpha and testis morphology during testicular hypertrophy subsequent to hemicastration in the neonatal boar. Wells R, et al. Mol Reprod Dev, 2008 Jun. PMID 18278782
    3. PEDE (Pig EST Data Explorer) has been expanded into Pig Expression Data Explorer, including 10 147 porcine full-length cDNA sequences. Uenishi H, et al. Nucleic Acids Res, 2007 Jan. PMID 17145712, Free PMC Article
    4. PEDE (Pig EST Data Explorer): construction of a database for ESTs derived from porcine full-length cDNA libraries. Uenishi H, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681463, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Process Evidence Code Pubs
    involved_in epidermal growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of epidermal growth factor-activated receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of mitotic nuclear division IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protransforming growth factor alpha

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_214251.1 → NP_999416.1  protransforming growth factor alpha precursor

      See identical proteins and their annotated locations for NP_999416.1

      Status: PROVISIONAL

      Source sequence(s)
      X71014
      UniProtKB/Swiss-Prot
      Q06922
      UniProtKB/TrEMBL
      A0A8D0K2Q4
      Related
      ENSSSCP00000008889.2, ENSSSCT00000009118.4
      Conserved Domains (2) summary
      PHA02887
      Location:44 → 83
      PHA02887; EGF-like protein; Provisional
      PHA03099
      Location:47 → 121
      PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional

    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010445.4 Reference Sscrofa11.1 Primary Assembly

      Range
      71948232..72054257
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021085860.1 → XP_020941519.1  protransforming growth factor alpha isoform X1

      UniProtKB/TrEMBL
      A0A8D0K2Q4
      Conserved Domains (1) summary
      cl28647
      Location:43 → 82
      PHA02887; EGF-like protein; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06922.1 GenPept UniProtKB/Swiss-Prot:Q06922

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.