IFNG interferon gamma [Sus scrofa (pig)] - Gene

Summary

Official Symbol: IFNGprovided by VGNC
Official Full Name: interferon gammaprovided by VGNC
Primary source: VGNC:VGNC:89040
See related: Ensembl:ENSSSCG00000032963
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Expression: Broad expression in spleen (RPKM 1.4), lung (RPKM 1.0) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	5	NC_010447.5 (32477906..32482670, complement)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	5	NC_010447.4 (35374421..35379185)

Chromosome 5 - NC_010447.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

IFN-gamma plays a crucial role in curtailing enteric coronavirus infection and may serve as an effective prophylactic and/or therapeutic agent against transmissible gastroenteritis virus infection.
Title: Interferon gamma inhibits transmissible gastroenteritis virus infection mediated by an IRF1 signaling pathway.
The regulatory effect of IFN-gamma on CYP3A29 expression is mediated via PXR.
Title: IFN-γ regulates cytochrome 3A29 through pregnane X receptor in pigs.
Mapping of QTL for mycoplasma and tetanus antibodies and IFNgamma.
Title: Mapping of quantitative trait loci for mycoplasma and tetanus antibodies and interferon-gamma in a porcine F(2) Duroc x Pietrain resource population.
Data show taht the expression of PoIFN-gamma in insect cells was confirmed by Western Blot, indirect immunofluorescence assay and indirect ELISA.
Title: [Expression of porcine gamma-interferon in recombinant baculovirus and determination of its antiviral activity].
IFNgamma production from the frozen peripheral blood mononuclear cells was significantly higher than that from the fresh ones.
Title: Effect of cryopreservation on IL-4, IFNgamma and IL-6 production of porcine peripheral blood lymphocytes.
The expression of IFN-gamma in recombiannt Lactococcus lactis as a tool for investigating downregulation of allergic predisposition of pigs to experimental food allergy is reported.
Title: Expression of bioactive porcine interferon-gamma by recombinant Lactococcus lactis.
A functional single nucleotide polymorphism is reported in the coding region of IFN-gamma cDNA that markedly reduces antiviral activity of the IFN-gamma protein.
Title: A missense polymorphism in porcine interferon-gamma cDNA affects antiviral activity of the protein variant.
Translational control of IL-18 expression by its 5'-UTR limits production of IL-18, resulting in restricted expression of mRNA and protein IFN-gamma in this model of crescentic glomerulonephritis(GN). Might amplify CD8+-mediated macrophage-dependent GN.
Title: IL-18 translational inhibition restricts IFN-gamma expression in crescentic glomerulonephritis.
selective changes in immature crypt cells induced by IFN-gamma bound to extracellular matrix could contribute to inappropriate responsiveness to commensal bacteria in inflammatory bowel diseases
Title: Interferon gamma bound to extracellular matrix changes the hyporesponsiveness to LPS in crypt but not villous intestinal epithelial cells.

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General gene information

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Markers

GAMMA (e-PCR), detects polymorphism
- UniSTS:251844

IFNG (e-PCR), detects polymorphism
- UniSTS:253668

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables type II interferon receptor binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in immune response	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: interferon gamma

Names: IFN-gamma

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.