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    DCN decorin [ Sus scrofa (pig) ]

    Gene ID: 396957, updated on 5-Mar-2024

    Summary

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    Official Symbol
    DCNprovided by VGNC
    Official Full Name
    decorinprovided by VGNC
    Primary source
    VGNC:VGNC:103228
    See related
    Ensembl:ENSSSCG00000000915
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
    Expression
    Broad expression in subcutaneous adipose (RPKM 1063.3), ovary (RPKM 1051.7) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See DCN in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) 5 NC_010447.5 (91678601..91713925)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) 5 NC_010447.4 (96109666..96144030)

    Chromosome 5 - NC_010447.5Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102159120 Neighboring gene uncharacterized LOC102159901 Neighboring gene lumican Neighboring gene keratocan

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Transcriptome data used for gene annotation
    • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
    • BioProject: PRJNA311523
    • Publication: PMID 27646534
    • Analysis date: Thu Dec 14 17:10:49 2017

    Bibliography

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    Related articles in PubMed

    1. Decorin and biglycan retain LDL in disease-prone valvular and aortic subendothelial intimal matrix. Neufeld EB, et al. Atherosclerosis, 2014 Mar. PMID 24529131, Free PMC Article
    2. Expression and genomic imprinting of DCN, PON2 and PEG3 genes in porcine placenta. Zhou QY, et al. Anim Reprod Sci, 2011 Jan. PMID 21232885
    3. Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury. Barallobre-Barreiro J, et al. Circulation, 2012 Feb 14. PMID 22261194
    4. PEDE (Pig EST Data Explorer): construction of a database for ESTs derived from porcine full-length cDNA libraries. Uenishi H, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681463, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LDL electrostatic interactions with decorin and biglycan in the aortic valve leaflets and vascular wall is a major source of LDL retention.
      Title: Decorin and biglycan retain LDL in disease-prone valvular and aortic subendothelial intimal matrix.
    2. The expression of the DCN gene increased from gestational day 26 to 90 in both Yorkshire and Meishan pig placenta.
      Title: Expression and genomic imprinting of DCN, PON2 and PEG3 genes in porcine placenta.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    decorin
    Names
    PG-S2
    bone proteoglycan II

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213920.1 → NP_999085.1  decorin precursor

      See identical proteins and their annotated locations for NP_999085.1

      Status: PROVISIONAL

      Source sequence(s)
      AF125537
      UniProtKB/Swiss-Prot
      Q9XSD9, Q9XSH4
      UniProtKB/TrEMBL
      A0A480UK19, A0A4X1SGJ1, A0A8D1GUN7
      Related
      ENSSSCP00000073505.1, ENSSSCT00000089888.1
      Conserved Domains (5) summary
      smart00013
      Location:54 → 84
      LRRNT; Leucine rich repeat N-terminal domain
      cd00116
      Location:42 → 284
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:295 → 308
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:63 → 85
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:87 → 142
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010447.5 Reference Sscrofa11.1 Primary Assembly

      Range
      91678601..91713925
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XSD9.1 GenPept UniProtKB/Swiss-Prot:Q9XSD9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials