Hrh1 histamine receptor H 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Hrh1provided by RGD
Official Full Name: histamine receptor H 1provided by RGD
Primary source: RGD:2830
See related: EnsemblRapid:ENSRNOG00000007420 AllianceGenome:RGD:2830
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Hisr
Summary: Enables histamine binding activity. Involved in several processes, including negative regulation of steroid biosynthetic process; positive regulation of nitric oxide biosynthetic process; and positive regulation of vasoconstriction. Predicted to be located in cytosol. Predicted to be active in dendrite and plasma membrane. Orthologous to human HRH1 (histamine receptor H1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: 4q42

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (149120511..149204267)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (147564963..147649353)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (146374596..146458148)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The role of histamine H1 receptor in the anterior cingulate cortex on nociception level following acute restraint stress in male rats.
Title: The role of histamine H(1) receptor in the anterior cingulate cortex on nociception level following acute restraint stress in male rats.
Increased Nuclear FOXP2 Is Related to Reduced Neural Stem Cell Number and Increased Neurogenesis in the Dorsal Telencephalon of Embryos of Diabetic Rats through Histamine H1 Receptors.
Title: Increased Nuclear FOXP2 Is Related to Reduced Neural Stem Cell Number and Increased Neurogenesis in the Dorsal Telencephalon of Embryos of Diabetic Rats through Histamine H(1) Receptors.
P2X4 Receptors Mediate Ca(2+) Release from Lysosomes in Response to Stimulation of P2X7 and H1 Histamine Receptors.
Title: P2X4 Receptors Mediate Ca(2+) Release from Lysosomes in Response to Stimulation of P2X7 and H(1) Histamine Receptors.
the histaminergic afferent inputs in the striatum may modulate both dopamine D1 and D2 receptor-expressing medium spiny projection neurons by activation of postsynaptic histamine H1 and H2 receptors.
Title: Histamine Excites Striatal Dopamine D1 and D2 Receptor-Expressing Neurons via Postsynaptic H1 and H2 Receptors.
Data (including data from studies in knockout mice) suggest that sleep-promoting effect of dietary supplement rice bran is dependent on Hrh1 antagonism; rice bran fully inhibits Hrh1 agonist-induced increase in action potential frequency in tuberomammillary nucleus neurons.
Title: A novel neurological function of rice bran: a standardized rice bran supplement promotes non-rapid eye movement sleep in mice through histamine H(1) receptors.
findings indicate that histamine H1, H2, and H3 receptors are present in rat olfactory epithelium and may play a physiological role in olfactory transmission.
Title: Expression and localization of histamine H(1), H(2), and H(3) receptors in rat olfactory epithelium.
This study demonstrates that AITC-induced nociception in vivo depends on TRPA1 and is decreased by the blockade of the NK1 receptor for SP, the H1 receptor for histamine and the 5-HT1A and 3 receptors for 5-HT
Title: TRPA1, substance P, histamine and 5-hydroxytryptamine interact in an interdependent way to induce nociception.
An H1 receptor blocker did not affect exercise-induced improvement in learning and memory in rats, so these receptors may not play a role in this process.
Title: The role of the central histaminergic receptors in the exercise-induced improvements of the spatial learning and memory in rats.
Isolated rat mesenteric collecting lymphatics were treated with 1- to 100-muM histamine. Pharmacologic blockade of either H1 or H2 histamine receptors significantly inhibited the response to histamine.
Title: Involvement of H1 and H2 receptors and soluble guanylate cyclase in histamine-induced relaxation of rat mesenteric collecting lymphatics.
Activation of H1R was required dopaminergic lineage during ventral midbrain development.
Title: Histamine impairs midbrain dopaminergic development in vivo by activating histamine type 1 receptors.

Submit: New GeneRIF Correction See all GeneRIFs (30)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables histamine binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables histamine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables histamine receptor activity	IEA Inferred from Electronic Annotation more info
enables histamine receptor activity	ISO Inferred from Sequence Orthology more info
enables histamine receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables histamine receptor activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger	TAS Traceable Author Statement more info	PubMed
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled serotonin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cellular response to histamine	IEA Inferred from Electronic Annotation more info
involved_in cellular response to histamine	ISO Inferred from Sequence Orthology more info
involved_in cellular response to histamine	ISS Inferred from Sequence or Structural Similarity more info
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in memory	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within memory	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of steroid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of nitric oxide biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of vasoconstriction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of vasoconstriction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synaptic plasticity	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of synaptic plasticity	ISO Inferred from Sequence Orthology more info
involved_in regulation of vascular permeability	IEA Inferred from Electronic Annotation more info
involved_in response to gravity	IEP Inferred from Expression Pattern more info	PubMed
involved_in visual learning	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within visual learning	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: histamine H1 receptor

Names: H1R; HH1R

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017018.2 → NP_058714.2 histamine H1 receptor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

UniProtKB/TrEMBL

A6IBV0, G3V6X5

Related

ENSRNOP00000109554.1, ENSRNOT00000124731.1

Conserved Domains (1) summary

cd15050
Location:29 → 478

7tmA_Histamine_H1R; histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

149120511..149204267

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039107019.2 → XP_038962947.1 histamine H1 receptor isoform X1

UniProtKB/Swiss-Prot

P31390

UniProtKB/TrEMBL

A6IBV0, G3V6X5

Related

ENSRNOP00000103271.1, ENSRNOT00000156547.1

Conserved Domains (1) summary

cd15050
Location:29 → 478

7tmA_Histamine_H1R; histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors