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    Hr3 Hormone receptor 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36073, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Hr3provided by FlyBase
    Official Full Name
    Hormone receptor 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0000448
    Locus tag
    Dmel_CG33183
    See related
    AllianceGenome:FB:FBgn0000448
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    12.6; 2.4; CG11823; CG12208; CG33183; D; dhr3; dHR3; Dhr3; DHR3; Dmel\CG33183; DmHr3; DmRORalpha; HR3; hr46; Hr46; l(2)46CFi; l(2)k09242; NR1F4
    Summary
    Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity and nuclear receptor activity. Involved in compound eye photoreceptor fate commitment; negative regulation of transcription by RNA polymerase II; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including embryonic/larval midgut primordium; epithelium; gut section; ring gland; and visceral mesoderm derivative. Human ortholog(s) of this gene implicated in idiopathic generalized epilepsy 15 and immunodeficiency 42. Orthologous to human RORA (RAR related orphan receptor A); RORB (RAR related orphan receptor B); and RORC (RAR related orphan receptor C). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
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    Genomic context

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    See Hr3 in Genome Data Viewer
    Location:
    46F5-46F7; 2-62 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (10203995..10237348, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (6091500..6124853, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene KCNQ potassium channel Neighboring gene mulet Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR46322 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45265 Neighboring gene Histidine decarboxylase Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Basis for selective action of a synthetic molting hormone agonist, RH-5992 on lepidopteran insects. Sundaram M, et al. Insect Biochem Mol Biol, 1998 Sep. PMID 9755479
    2. An ecdysteroid-inducible Manduca gene similar to the Drosophila DHR3 gene, a member of the steroid hormone receptor superfamily. Palli SR, et al. Dev Biol, 1992 Apr. PMID 1372571
    3. Early-late genes of the ecdysone cascade as models for transcriptional studies. Mazina MY, et al. Cell Cycle, 2015. PMID 26506480, Free PMC Article
    4. The nuclear receptor Hr46/Hr3 is required in the blood brain barrier of mature males for courtship. Lama C, et al. PLoS Genet, 2022 Jan. PMID 35077443, Free PMC Article
    5. Highly flexible ligand binding pocket of ecdysone receptor: a single amino acid change leads to discrimination between two groups of nonsteroidal ecdysone agonists. Kumar MB, et al. J Biol Chem, 2004 Jun 25. PMID 15107428

    See all (180) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The nuclear receptor Hr46/Hr3 is required in the blood brain barrier of mature males for courtship.
      Title: The nuclear receptor Hr46/Hr3 is required in the blood brain barrier of mature males for courtship.
    2. DHR3 and Hr4 gene expression is dose dependent, is completely controlled by the hormone titer and decreases within hours of 20-hydroxyecdysone withdrawal.
      Title: Early-late genes of the ecdysone cascade as models for transcriptional studies.
    3. DHR3 and betaFTZ-F1 activate the EDG84A gene in a redundant manner. The temporal expression of the EDG84A gene is mainly controlled by betaFTZ-F1 but that the binding of DHR3 is also important.
      Title: The binding of multiple nuclear receptors to a single regulatory region is important for the proper expression of EDG84A in Drosophila melanogaster.
    4. SAYP interacts with DHR3 nuclear receptor and activates the corresponding genes by recruiting the BTFly (Brahma and TFIID) coactivator supercomplex during development and have multiple common targets across the genome.
      Title: [SAYP interacts with DHR3 nuclear receptor and participates in ecdysone-dependent transcription regulation].
    5. DHR3 and SAYP interact during development and have multiple common targets across the genome
      Title: SAYP interacts with DHR3 nuclear receptor and participates in ecdysone-dependent transcription regulation.
    6. DHR3 modulates dS6 kinase-dependent growth in Drosophila.
      Title: The nuclear receptor DHR3 modulates dS6 kinase-dependent growth in Drosophila.
    7. Mid-embryonic expression of DHR3 and betaFTZ-F1 is part of a 20-hydroxyecdysone (20E)-triggered transcriptional cascade, directing maximal expression of E74A and E75A during late embryogenesis.
      Title: The Drosophila nuclear receptors DHR3 and betaFTZ-F1 control overlapping developmental responses in late embryos.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nuclear receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nuclear receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclear receptor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in compound eye photoreceptor fate commitment IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in metamorphosis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of development, heterochronic TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    hormone receptor 3
    Names
    CG33183-PA
    CG33183-PC
    CG33183-PD
    CG33183-PF
    CG33183-PH
    CG33183-PI
    Hr3-PA
    Hr3-PC
    Hr3-PD
    Hr3-PF
    Hr3-PH
    Hr3-PI
    complementation group D
    hormone receptor-like 46
    hormone receptor-like in 46
    NP_001334718.1
    • non-AUG (ACG) translation initiation

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      10203995..10237348 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001347757.1 → NP_001334718.1  hormone receptor 3, isoform I [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A384SX09

    2. NM_001259307.3 → NP_001246236.1  hormone receptor 3, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246236.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P31396, Q9V5I0
      UniProtKB/TrEMBL
      A2VEG1, H1UUN3
      Conserved Domains (2) summary
      cd06968
      Location:44 → 138
      NR_DBD_ROR; DNA-binding domain of Retinoid-related orphan receptors (RORs) is composed of two C4-type zinc fingers
      cl11397
      Location:236 → 478
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

    3. NM_001103786.2 → NP_001097256.1  hormone receptor 3, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097256.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DY91, Q8SXA4
      Conserved Domains (2) summary
      cd06968
      Location:15 → 109
      NR_DBD_ROR; DNA-binding domain of Retinoid-related orphan receptors (RORs) is composed of two C4-type zinc fingers
      cl11397
      Location:205 → 447
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

    4. NM_176121.3 → NP_788301.1  hormone receptor 3, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788301.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z858
      Related
      FBpp0087454
      Conserved Domains (2) summary
      cd06968
      Location:253 → 347
      NR_DBD_ROR; DNA-binding domain of Retinoid-related orphan receptors (RORs) is composed of two C4-type zinc fingers
      cl11397
      Location:443 → 685
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

    5. NM_176123.5 → NP_788303.1  hormone receptor 3, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788303.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P31396, Q9V5I0
      UniProtKB/TrEMBL
      A2VEG1, H1UUN3
      Related
      FBpp0087456
      Conserved Domains (2) summary
      cd06968
      Location:44 → 138
      NR_DBD_ROR; DNA-binding domain of Retinoid-related orphan receptors (RORs) is composed of two C4-type zinc fingers
      cl11397
      Location:236 → 478
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

    6. NM_001273925.2 → NP_001260854.1  hormone receptor 3, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260854.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KEJ3, A2VEG1
      Conserved Domains (2) summary
      cd06968
      Location:44 → 138
      NR_DBD_ROR; DNA-binding domain of Retinoid-related orphan receptors (RORs) is composed of two C4-type zinc fingers
      cl11397
      Location:236 → 478
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KEJ3 A0A0B4KEJ3
    A0A384SX09 A0A384SX09
    A1Z858 A1Z858
    A8DY91 A8DY91
    H1UUN3 H1UUN3
    P31396.1 P31396
    Q8SXA4 Q8SXA4

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