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    IL1B interleukin 1 beta [ Macaca fascicularis (crab-eating macaque) ]

    Gene ID: 102119749, updated on 7-Jun-2024

    Summary

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    Gene symbol
    IL1B
    Gene description
    interleukin 1 beta
    See related
    Ensembl:ENSMFAG00000043064
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Macaca fascicularis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See IL1B in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_05 current T2T-MFA8v1.0 (GCF_037993035.1) 13 NC_088387.1 (19833045..19839786, complement)
    102 previous assembly MFA1912RKSv2 (GCF_012559485.2) 13 NC_052267.1 (15917897..15924639, complement)

    Chromosome 13 - NC_088387.1Genomic Context describing neighboring genes Neighboring gene 5'-nucleotidase domain containing 4 Neighboring gene cytoskeleton associated protein 2 like Neighboring gene uncharacterized LOC123568343 Neighboring gene interleukin 1 alpha Neighboring gene baculoviral IAP repeat-containing protein 8 Neighboring gene uncharacterized LOC135966779

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and expression of cynomolgus monkey interleukin-1beta cDNA. Totsuka K, et al. Int Arch Allergy Immunol, 1998 May. PMID 9623508
    2. Interleukin-1β and tumor necrosis factor-α affect cytochrome P450 expression in cynomolgus macaque hepatocytes. Uno Y, et al. Drug Metab Pharmacokinet, 2020 Jun. PMID 32253084
    3. A single amino acid difference between human and monkey interleukin (IL)-1beta dictates effective binding to soluble type II IL-1 receptor. Smith DE, et al. J Biol Chem, 2002 Dec 6. PMID 12356774
    4. Collection of Macaca fascicularis cDNAs derived from bone marrow, kidney, liver, pancreas, spleen, and thymus. Osada N, et al. BMC Res Notes, 2009 Sep 29. PMID 19785770, Free PMC Article
    5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Interleukin-1beta and tumor necrosis factor-alpha affect cytochrome P450 expression in cynomolgus macaque hepatocytes.
      Title: Interleukin-1β and tumor necrosis factor-α affect cytochrome P450 expression in cynomolgus macaque hepatocytes.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cytokine activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables interleukin-1 receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cytokine-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of immature T cell proliferation in thymus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of nitric-oxide synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    interleukin-1 beta
    Names
    IL-1 beta

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001283569.1 → NP_001270498.1  interleukin-1 beta

      Status: VALIDATED

      Source sequence(s)
      BLPH02000013, D63353, DC855259
      UniProtKB/Swiss-Prot
      P79182
      UniProtKB/TrEMBL
      A0A2K5VDC7, G7PMZ7
      Conserved Domains (2) summary
      smart00125
      Location:119 → 265
      IL1; Interleukin-1 homologues
      pfam02394
      Location:1 → 102
      IL1_propep; Interleukin-1 propeptide

    RefSeqs of Annotated Genomes: GCF_037993035.1-RS_2024_05

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference T2T-MFA8v1.0

    Genomic

    1. NC_088387.1 Reference T2T-MFA8v1.0

      Range
      19833045..19839786 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P79182.1 GenPept UniProtKB/Swiss-Prot:P79182

    Gene LinkOut

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