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    ARHGEF25 Rho guanine nucleotide exchange factor 25 [ Sus scrofa (pig) ]

    Gene ID: 100517400, updated on 17-Aug-2024

    Summary

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    Official Symbol
    ARHGEF25provided by VGNC
    Official Full Name
    Rho guanine nucleotide exchange factor 25provided by VGNC
    Primary source
    VGNC:VGNC:103216
    See related
    Ensembl:ENSSSCG00000000435
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
    Expression
    Broad expression in ovary (RPKM 21.6), subcutaneous adipose (RPKM 10.8) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See ARHGEF25 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) 5 NC_010447.5 (22873502..22880830)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) 5 NC_010447.4 (24726679..24733774, complement)

    Chromosome 5 - NC_010447.5Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol-5-phosphate 4-kinase type 2 gamma Neighboring gene deltex E3 ubiquitin ligase 3 Neighboring gene solute carrier family 26 member 10 Neighboring gene beta-1,4-N-acetyl-galactosaminyltransferase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
    • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
    • BioProject: PRJNA311523
    • Publication: PMID 27646534
    • Analysis date: Thu Dec 14 17:10:49 2017

    Bibliography

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    Related articles in PubMed

    1. PEDE (Pig EST Data Explorer) has been expanded into Pig Expression Data Explorer, including 10 147 porcine full-length cDNA sequences. Uenishi H, et al. Nucleic Acids Res, 2007 Jan. PMID 17145712, Free PMC Article
    2. PEDE (Pig EST Data Explorer): construction of a database for ESTs derived from porcine full-length cDNA libraries. Uenishi H, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681463, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in axon guidance IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    rho guanine nucleotide exchange factor 25
    Names
    Rho guanine nucleotide exchange factor (GEF) 25

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010447.5 Reference Sscrofa11.1 Primary Assembly

      Range
      22873502..22880830
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021091874.1 → XP_020947533.1  rho guanine nucleotide exchange factor 25 isoform X2

      UniProtKB/TrEMBL
      A0A481CXC2
      Conserved Domains (2) summary
      cd13241
      Location:373 → 515
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      pfam00621
      Location:198 → 368
      RhoGEF; RhoGEF domain

    2. XM_003126313.5 → XP_003126361.1  rho guanine nucleotide exchange factor 25 isoform X1

      UniProtKB/TrEMBL
      A0A287AZL6, A0A481CXC2, A0A4X1W4U4, A0A8D1VNE4, F1SKH7
      Related
      ENSSSCP00000049410.2, ENSSSCT00000038624.3
      Conserved Domains (2) summary
      cd13241
      Location:381 → 523
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      pfam00621
      Location:206 → 377
      RhoGEF; RhoGEF domain

    3. XM_005663932.3 → XP_005663989.1  rho guanine nucleotide exchange factor 25 isoform X3

      UniProtKB/TrEMBL
      A0A481CXC2, A0A4X1W012, A0A8D0K0Q0, F1SKH1
      Related
      ENSSSCP00000000469.3, ENSSSCT00000000476.5
      Conserved Domains (2) summary
      cd13241
      Location:349 → 491
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      pfam00621
      Location:174 → 345
      RhoGEF; RhoGEF domain

    4. XM_013997659.2 → XP_013853113.1  rho guanine nucleotide exchange factor 25 isoform X6

      UniProtKB/TrEMBL
      A0A481CXC2
      Conserved Domains (2) summary
      cd13241
      Location:283 → 425
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      pfam00621
      Location:108 → 279
      RhoGEF; RhoGEF domain

    5. XM_021091875.1 → XP_020947534.1  rho guanine nucleotide exchange factor 25 isoform X5

      UniProtKB/TrEMBL
      A0A480P7Y5, A0A8D0TVB9
      Conserved Domains (2) summary
      cd13241
      Location:307 → 449
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      pfam00621
      Location:132 → 302
      RhoGEF; RhoGEF domain

    6. XM_003126314.5 → XP_003126362.1  rho guanine nucleotide exchange factor 25 isoform X4

      UniProtKB/TrEMBL
      A0A287BEY8, A0A480P7Y5, A0A4X1W5S2, A0A8D1D4J9
      Related
      ENSSSCP00000054690.2, ENSSSCT00000057246.3
      Conserved Domains (2) summary
      cd13241
      Location:339 → 481
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      pfam00621
      Location:164 → 335
      RhoGEF; RhoGEF domain
    Nucleotide Protein
    Heading Accession and Version

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